Web of Science: 109 cites, Scopus: 110 cites, Google Scholar: cites,
Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan
Franke, Barbara (Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands)
Michelini, Giorgia (King's College London, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, London, UK)
Asherson, Philip (King's College London, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, London, UK)
Banaschewski, Tobias (Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany)
Bilbow, Andrea (ADHD-Europe, Brussels, Belgium)
Buitelaar, Jan K. (Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, The Netherlands)
Cormand, Bru (Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Catalonia, Spain)
Faraone, Stephen V. (K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway)
Ginsberg, Ylva (Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden)
Haavik, Jan (Division of Psychiatry, Haukeland University Hospital, Bergen, Norway)
Kuntsi, Jonna (King's College London, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, London, UK)
Larsson, Henrik (Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden)
Lesch, Klaus-Peter (Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands)
Ramos-Quiroga, J. Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Réthelyi, János M. (MTA-SE NAP-B Molecular Psychiatry Research Group, Hungarian Academy of Sciences, Budapest, Hungary)
Ribases, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Reif, Andreas (Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany)

Data: 2018
Resum: Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a substantial number of cases the disorder does not remit in puberty, but persists into adulthood. Both in childhood and adulthood, ADHD is characterised by substantial comorbidity including substance use, depression, anxiety, and accidents. However, course and symptoms of the disorder and the comorbidities may fluctuate and change over time, and even age of onset in childhood has recently been questioned. Available evidence to date is poor and largely inconsistent with regard to the predictors of persistence versus remittance. Likewise, the development of comorbid disorders cannot be foreseen early on, hampering preventive measures. These facts call for a lifespan perspective on ADHD from childhood to old age. In this selective review, we summarise current knowledge of the long-term course of ADHD, with an emphasis on clinical symptom and cognitive trajectories, treatment effects over the lifespan, and the development of comorbidities. Also, we summarise current knowledge and important unresolved issues on biological factors underlying different ADHD trajectories. We conclude that a severe lack of knowledge on lifespan aspects in ADHD still exists for nearly every aspect reviewed. We encourage large-scale research efforts to overcome those knowledge gaps through appropriately granular longitudinal studies.
Nota: Altres ajuts: This study has been produced by members of the "International Multicentre persistent ADHD Collaboration" (IMpACT; www.impactadhdgenomics.com) and the ECNP for the Research Network "ADHD across the Lifespan" (https://www.ecnp.eu/research-innovation/ECNP-networks/List-ECNP-Networks/ADHD.aspx). IMpACT unites major research centres working on the genetics of ADHD persistence across the lifespan and has participants in the Netherlands, Germany, Spain, Norway, the United Kingdom, the United States, Brazil, and Sweden. Principal investigators of IMpACT are: Barbara Franke (chair), Andreas Reif (co-chair), Stephen V. Faraone, Jan Haavik, Bru Cormand, J. Antoni Ramos-Quiroga, Philip Asherson, Klaus-Peter Lesch, Jonna Kuntsi, Claiton H.D. Bau, Jan K. Buitelaar, Stefan Johansson, Henrik Larsson, Alysa Doyle, and Eugenio H. Grevet. Their work is supported by European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 602805 (AGGRESSOTYPE), 603016 (MATRICS), 278948 (TACTICS), 602450 (IMAGEMEND) and from the European Community's Horizon 2020 Programme (H2020/2014 - 2020). Barbara Franke also receives support from the Netherlands Organization for Scientific Research (NWO), i.e. the Vici Innovation Program (grant 016-130-669). Andreas Reif is supported by the BMBF (BipoLife) and the DFG (CRC 1193, C07 and Z03). János M. Réthelyi is supported by the Hungarian Brain Research Program (Grant NAP-B KTIA_NAP_13-2014-0011). Giorgia Michelini was supported by a 1 + 3 PhD studentship awarded by the MRC Social, Genetic & Developmental Psychiatry Centre, King's College London (G9817803). Bru Cormand received support from the Spanish "Ministerio de Economía y Competitividad" and AGAUR, "Generalitat de Catalunya". J. Antoni Ramos-Quiroga received support by Instituto de Salud Carlos III, and cofinanced by Agència de Gestió d'Ajuts Universitaris i de Recerca-AGAUR, Generalitat de Catalunya, Departament de Salut, Generalitat de Catalunya, Spain. Marta Ribases received support from the Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad, Spain and from a NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation. The funders had no further role in the writing of this manuscript and in the decision to submit it for publication.
Nota: Número d'acord de subvenció MINECO/SAF2015-68341-R
Nota: Número d'acord de subvenció AGAUR/2014/SGR932
Nota: Número d'acord de subvenció ISCIII/PI12-01139
Nota: Número d'acord de subvenció ISCIII/PI15-01789
Nota: Número d'acord de subvenció AGAUR/2014/SGR1357
Nota: Número d'acord de subvenció AGAUR/2014/SGR0932
Nota: Número d'acord de subvenció ISCIII/MINECO/CP09-00119
Nota: Número d'acord de subvenció ISCIII/MINECO/CPII15-00023
Nota: Número d'acord de subvenció ISCIII/MINECO/PI14-01700
Nota: Número d'acord de subvenció ISCIII/MINECO/PI17-00289
Nota: Número d'acord de subvenció EC/H2020/643051
Nota: Número d'acord de subvenció EC/H2020/667302
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; article de revisió ; publishedVersion
Matèria: Developmental trajectory ; Treatment ; Comorbidity ; Cognitive impairment ; Genetics ; Adult-onset ADHD
Publicat a: European Neuropsychopharmacology, Vol. 28 (october 2018) , p. 1059-1088, ISSN 1873-7862

DOI: 10.1016/j.euroneuro.2018.08.001
PMID: 30195575


30 p, 2.0 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2020-07-13, darrera modificació el 2021-04-15



   Favorit i Compartir