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| Home > Articles > Published articles > Epigenetic-Transcriptional Regulation of Fatty Acid Metabolism and Its Alterations in Leukaemia |
| Home > Articles > Published articles > Epigenetic-Transcriptional Regulation of Fatty Acid Metabolism and Its Alterations in Leukaemia |
(Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)| Date: | 2018 |
| Abstract: | In recent years fatty acid metabolism has gained greater attention in haematologic cancers such as acute myeloid leukaemia. The oxidation of fatty acids provides fuel in the form of ATP and NADH, while fatty acid synthesis provides building blocks for cellular structures. Here, we will discuss how leukaemic cells differ from healthy cells in their increased reliance on fatty acid metabolism. In order to understand how these changes are achieved, we describe the main pathways regulating fatty acid metabolism at the transcriptional level and highlight the limited knowledge about related epigenetic mechanisms. We explore these mechanisms in the context of leukaemia and consider the relevance of the bone marrow microenvironment in disease management. Finally, we discuss efforts to interfere with fatty acid metabolism as a therapeutic strategy along with the use of metabolic parameters as biomarkers. |
| Grants: | Ministerio de Economía y Competitividad ISCIII/CD17-00084 Ministerio de Economía y Competitividad ISCIII/PIE16-00011 Ministerio de Economía y Competitividad ISCIII/BFU2015-66559-P Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-305 |
| Note: | Altres ajuts: MM is supported by the Marie Skłodowska Curie Training network ChroMe (H2020-MSCA-ITN-2015-675610) and JD by a postdoctoral Sara Borrell fellowship from MINECO-ISCIII. Research in the Buschbeck lab is further supported by grants from MINECO-ISCIII, MINECO, the Deutsche Jose Carreras Leukaemie Stiftung and AGAUR . Research at the IJC is supported by the La Caixa Foundation, the Fundació Internacional Josep Carreras, Celgene Spain and the CERCA Programme/Generalitat de Catalunya. |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Cancer ; AML ; Fatty acid metabolism ; Fatty acid oxidation ; Epigenetics ; CPT1 ; Transcription |
| Published in: | Frontiers in genetics, Vol. 9 (september 2018) , ISSN 1664-8021 |
