Mucin expression in gastric- and gastro-oesophageal signet-ring cell cancer : results from a comprehensive literature review and a large cohort study of Caucasian and Asian gastric cancer
Kerckhoffs, K. G. P. (Maastricht University Medical Center+. Department of Pathology, GROW School for Oncology and Developmental Biology)
Liu, D. H. W. (Maastricht University Medical Center+. Department of Pathology, GROW School for Oncology and Developmental Biology)
Saragoni, L. (Morgagni-Pierantoni Hospital. Pathology Unit)
van der Post, R. S. (Radboudumc. Department of Pathology)
Langer, R. (University of Bern. Institute of Pathology)
Bencivenga, Maria (University of Verona. Unit of General and Upper GI Surgery)
Iglesias, Mar (Hospital del Mar (Barcelona, Catalunya))
Gallo, Giorgio (Azienda Ospedaliero-Universitaria Policlinico di Modena. Department of Anatomic Pathology)
Hewitt, L. C. (Maastricht University Medical Center+. Department of Pathology, GROW School for Oncology and Developmental Biology)
Fazzi, G. E. (Maastricht University Medical Center+. Department of Pathology, GROW School for Oncology and Developmental Biology)
Vos, A. M. (Radboudumc. Department of Pathology)
Renaud, F. (Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020 - UMR-S 1277 - Canther - Cancer Heterogeneity, Plasticity and Resistance to Therapies. Department of Pathology)
Yoshikawa, T. (National Cancer Center Hospital. Department of Gastric Surgery)
Oshima, T. (Kanagawa Cancer Center. Department of Gastrointestinal Surgery)
Tomezzoli, A. (University Hospital of Verona (Itàlia))
De Manzoni, G.. (University of Verona. Unit of General and Upper GI Surgery)
Arai, T. (Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology. Department of Pathology)
Kushima, R. (Shiga University of Medical Science. Department of Pathology)
Carneiro, Fátima (Centro Hospitalar Universitário São João (Porto, Portugal))
Grabsch, H. I. (University of Leeds. Division of Pathology and Data Analytics, Leeds Institute of Medical Research at St. James's)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	The literature on the prognostic relevance of signet-ring cell (SRC) histology in gastric cancer (GC) is controversial which is most likely related to inconsistent SRC classification based on haematoxylin-eosin staining. We hypothesised that mucin stains can consistently identify SRC-GC and predict GC patient outcome. We performed a comprehensive literature review on mucin stains in SRC-GC and characterised the mucin expression in 851 Caucasian GC and 410 Asian GC using Alcian Blue (AB)-Periodic Acid-Schiff (PAS), MUC2 (intestinal-type mucin), and MUC5AC (gastric-type mucin). The relationship between mucin expression and histological phenotype [poorly cohesive (PC) including proportion of SRCs, non-poorly cohesive (non-PC), or mucinous (MC)], clinicopathological variables, and patient outcome was analysed. Depending on mucin expression and cut-offs, the positivity rates of SRC-GC reported in the literature varied from 6 to 100%. Patients with MUC2 positive SRC-GC or SRC-GC with (gastro)intestinal phenotype had poorest outcome. In our cohort study, PC with ≥ 10% SRCs expressed more frequently MUC2, MUC5AC, and ABPAS (p < 0. 001, p = 0. 004 and p < 0. 001, respectively). Caucasians with AB positive GC or combined ABPAS-MUC2 positive and MUC5AC negative had poorest outcome (all p = 0. 002). This association was not seen in Asian patients. This is the first study to suggest that mucin stains do not help to differentiate between SRC-GC and non-SRC-GC. However, mucin stains appear to be able to identify GC patients with different outcome. To our surprise, the relationship between outcome and mucin expression seems to differ between Caucasian and Asian GC patients which warrants further investigations. The online version of this article (10. 1007/s10120-020-01086-0) contains supplementary material, which is available to authorized users.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Gastric cancer ; Signet-ring cells ; Mucin ; Histological phenotype ; Survival
Publicat a:	Gastric Cancer, Vol. 23 (june 2020) , p. 765-779, ISSN 1436-3305

DOI: 10.1007/s10120-020-01086-0
PMID: 32488651

15 p, 1.4 MB

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