Mindfulness-Based Program Plus Amygdala and Insula Retraining (MAIR) for the Treatment of Women with Fibromyalgia : a Pilot Randomized Controlled Trial
Sanabria-Mazo, Juan P.. ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Facultat de Psicologia)
Gasión, Virginia (Instituto de Investigación Sanitaria de Aragón)
Navarro-Gil, Mayte ![Identificador ORCID](/img/uab/orcid.ico)
(Instituto de Investigación Sanitaria de Aragón)
Morillo, Héctor ![Identificador ORCID](/img/uab/orcid.ico)
(Universidad de Zaragoza. Facultad de Psicología)
Colomer-Carbonell, Ariadna ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Facultat de Psicologia)
Borràs, Xavier ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Facultat de Psicologia)
Tops, Mattie (Leiden University. Developmental and Educational Psychology Unit)
Luciano, Juan V.
(Parc Sanitari Sant Joan de Déu)
Garcia-Campayo, Javier
(RedIAPP (Red de Investigación en Actividades Preventivas y Promoción de la Salud))
Montero-Marín, Jesús
(University of Oxford. Department of Psychiatry)
Feliu-Soler, Albert
(Universitat Autònoma de Barcelona. Facultat de Psicologia)
Data: |
2020 |
Resum: |
The lack of highly effective treatments for fibromyalgia (FM) represents a great challenge for public health. The objective of this parallel, pilot randomized controlled trial (RCT) was two-fold: (1) to analyze the clinical effects of mindfulness plus amygdala and insula retraining (MAIR) compared to a structurally equivalent active control group of relaxation therapy (RT) in the treatment of FM; and (2) to evaluate its impact on immune-inflammatory markers and brain-derived neurotrophic factor (BDNF)in serum. A total of 41 FM patients were randomized into two study arms: MAIR (intervention group)and RT (active control group), both as add-ons of treatment as usual. MAIR demonstrated significantly greater reductions in functional impairment, anxiety, and depression, as well as higher improvements in mindfulness, and self-compassion at post-treatment and follow-up, with moderate to large effectsizes. Significant decreases in pain catastrophizing and psychological inflexibility and improvementsin clinical severity and health-related quality of life were found at follow-up, but not at post-treatment,showing large effect sizes. The number needed to treat was three based on the criteria of ≥50% Fibromyalgia Impact Questionnaire (FIQ) reduction post-treatment. Compared to RT, the MAIRshowed significant decreases in BDNF. No effect of MAIR was observed in immune-inflammatorybiomarkers (i. e. , TNF-α, IL-6, IL-10, and hs-CRP). In conclusion, these results suggest that MAIR, as an adjuvant of treatment-as-usual (TAU), appears to be effective for the management of FM symptomsand for reducing BDNF levels in serum. |
Ajuts: |
Instituto de Salud Carlos III RD16/0007/0005 Instituto de Salud Carlos III CPII19/00003 Instituto de Salud Carlos III FI20/00034
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Drets: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by.ico) |
Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
Fibromyalgia ;
Mindfulness ;
Amygdala and insula retraining ;
Mind-body techniques ;
Multicomponent intervention ;
Brain-derived neurotrophic factor ;
Immune-inflammatory markers ;
Randomized controlled trial ;
Pilot study |
Publicat a: |
Journal of clinical medicine, Vol. 9 Núm. 10 (2020) , p. 3246, ISSN 2077-0383 |
Adreça alternativa: https://www.mdpi.com/2077-0383/9/10/3246
DOI: 10.3390/jcm9103246
PMID: 33050630
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Registre creat el 2020-10-14, darrera modificació el 2024-03-19