B Cells and Tertiary Lymphoid Structures Influence Survival in Lung Cancer Patients with Resectable Tumors
Tang, Jun (Institut Hospital del Mar d'Investigacions Mèdiques)
Curull Serrano, Víctor (Institut Hospital del Mar d'Investigacions Mèdiques)
Wang, Xuejie (Institut Hospital del Mar d'Investigacions Mèdiques)
Mateu-Jiménez, Mercé (Institut Hospital del Mar d'Investigacions Mèdiques)
Pijuan, Lara (Institut Hospital del Mar d'Investigacions Mèdiques)
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
Qin, Liyun (Institut Hospital del Mar d'Investigacions Mèdiques)
Rodríguez-Fuster, Alberto (Institut Hospital del Mar d'Investigacions Mèdiques)
Aguiló Espases, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques)
Barreiro, Esther (Institut Hospital del Mar d'Investigacions Mèdiques)
Ramis-Cabrer, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques)
Universitat Autònoma de Barcelona
Fecha: |
2020 |
Resumen: |
Immune profile of B and T cells and tertiary lymphoid structures (TLSs) may differ in tumors of lung cancer (LC) patients with/without chronic obstructive pulmonary disease (COPD), and may also influence patient survival. We sought to analyze: (1) TLSs, germinal centers (GCs), B and T cells, and (2) associations of the immune biomarkers with the patients' 10-year overall survival (OS). TLSs (numbers and area), B [cluster of differentiation (CD) 20], and T (CD3), and GCs cells were identified in both tumor and non-tumor specimens (thoracotomy) from 90 LC-COPD patients and 43 LC-only patients. Ten-year OS was analyzed in the patients. Immune profile in tumors of LC-COPD versus LC: TLS numbers and areas significantly decreased in tumors of LC-COPD compared to LC patients. No significant differences were observed in tumors between LC-COPD and LC patients for B or T cells. Immune profile in tumors versus non-tumor specimens: TLS areas and B cells significantly increased, T cells significantly decreased in tumors of both LC and LC-COPD patients. Survival: in LC-COPD patients: greater area of TLSs and proportion of B cells were associated with longer survival rates. The immune tumor microenvironment differs in patients with underlying COPD and these different phenotypes may eventually impact the response to immunotherapy in patients with LC. |
Ayudas: |
Instituto de Salud Carlos III FIS 18-0007 Instituto de Salud Carlos III PT13-0010-0005
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Nota: |
Altres ajuts: This study has been supported bythe "Xarxa de Bancs de tumors sponsored by Pla Director d'Oncologia de Catalunya (XBTC)", Catalan Government. |
Derechos: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: |
Anglès |
Documento: |
Article ; recerca ; Versió publicada |
Materia: |
Lung cancer ;
Chronic respiratory diseases ;
Tertiary lymphoid structures ;
B cells ;
Overall survival |
Publicado en: |
Cancers, Vol. 12 Núm. 9 (2020) , p. 2644, ISSN 2072-6694 |
DOI: 10.3390/cancers12092644
PMID: 32947928
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Registro creado el 2020-11-04, última modificación el 2023-09-20