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| Página principal > Artículos > Artículos publicados > The Role of Sleep Quality, Trait Anxiety and Hypothalamic-Pituitary-Adrenal Axis Measures in Cognitive Abilities of Healthy Individuals |
(Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) (Hospital Universitari de Bellvitge) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) (Hospital Universitari Institut Pere Mata) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) (Hospital Universitari de Bellvitge) (Hospital Universitari de Bellvitge) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) (Universitat Autònoma de Barcelona. Institut de Neurociències) (Hospital Universitari Institut Pere Mata) (Hospital Universitari de Bellvitge) (Universitat Autònoma de Barcelona. Institut de Neurociències) (Hospital Universitari Institut Pere Mata)| Fecha: | 2020 |
| Resumen: | Sleep plays a crucial role in cognitive processes. Sleep and wake memory consolidation seem to be regulated by glucocorticoids, pointing out the potential role of the hypothalamic-pituitary-adrenal (HPA) axis in the relationship between sleep quality and cognitive abilities. Trait anxiety is another factor that is likely to moderate the relationship between sleep and cognition, because poorer sleep quality and subtle HPA axis abnormalities have been reported in people with high trait anxiety. The current study aimed to explore whether HPA axis activity or trait anxiety moderate the relationship between sleep quality and cognitive abilities in healthy individuals. We studied 203 healthy individuals. We measured verbal and visual memory, working memory, processing speed, attention and executive function. Sleep quality was assessed with the Pittsburgh Sleep Quality Index. Trait anxiety was assessed with the State-Trait Anxiety Inventory. HPA axis measures included the cortisol awakening response (CAR), diurnal cortisol slope and cortisol levels during the day. Multiple linear regression analyses explored the relationship between sleep quality and cognition and tested potential moderating effects by HPA axis measures and trait anxiety. Poor sleep quality was associated with poorer performance in memory, processing speed and executive function tasks. In people with poorer sleep quality, a blunted CAR was associated with poorer verbal and visual. |
| Resumen: | memory and executive functions, and higher cortisol levels during the day were associated with poorer processing speed. Trait anxiety was a moderator of visual memory and executive functioning. These results suggest that subtle abnormalities in the HPA axis and higher trait anxiety contribute to the relationship between lower sleep quality and poorer cognitive functioning in healthy individuals. |
| Ayudas: | Ministerio de Ciencia e Innovación PI10-01753 Ministerio de Ciencia e Innovación PI10-01607 Ministerio de Ciencia e Innovación PI15-01386 Ministerio de Ciencia e Innovación PI15-00662 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1247 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-632 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT006-17-00012 Instituto de Salud Carlos III INT19-00071 |
| Nota: | Altres ajuts: This study was supported in part by grants from the European Regional Development Fund (ERDF) "A way to build Europe", the Fundació La Marató de TV3 (092230/092231), CIBERSAM. Samples from patients included in this study were processed and preserved by the Biobank IISPV and the Biobank HUB-ICO-IDIBELL, integrated in the Spanish National Biobanks Network (PT17/0015/0024) and Xarxa Banc de Tumors. The funders had no role in the study design,data collection and analysis, decision to publish, or preparation of the manuscript. |
| Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Lengua: | Anglès |
| Documento: | Article ; recerca ; Versió publicada |
| Materia: | Sleep quality ; Memory ; Cortisol ; Trait anxiety |
| Publicado en: | International journal of environmental research and public health, Vol. 17 (2020) , p. 7600, ISSN 1660-4601 |
