Search for Reliable Circulating Biomarkers to Predict Carotid Plaque Vulnerability
Puig Grifol, Núria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Jiménez Xarrié, Elena (Institut d'Investigació Biomèdica Sant Pau)
Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau)
Benitez, Sonia (Institut d'Investigació Biomèdica Sant Pau)

Date:	2020
Abstract:	Atherosclerosis is responsible for 20% of ischemic strokes, and the plaques from the internal carotid artery the most frequently involved. Lipoproteins play a key role in carotid atherosclerosis since lipid accumulation contributes to plaque progression and chronic inflammation, both factors leading to plaque vulnerability. Carotid revascularization to prevent future vascular events is reasonable in some patients with high-grade carotid stenosis. However, the degree of stenosis alone is not sufficient to decide upon the best clinical management in some situations. In this context, it is essential to further characterize plaque vulnerability, according to specific characteristics (lipid-rich core, fibrous cap thinning, intraplaque hemorrhage). Although these features can be partly detected by imaging techniques, identifying carotid plaque vulnerability is still challenging. Therefore, the study of circulating biomarkers could provide adjunctive criteria to predict the risk of atherothrombotic stroke. In this regard, several molecules have been found altered, but reliable biomarkers have not been clearly established yet. The current review discusses the concept of vulnerable carotid plaque, and collects existing information about putative circulating biomarkers, being particularly focused on lipid-related and inflammatory molecules.
Grants:	Instituto de Salud Carlos III FIS PI19-00421 Instituto de Salud Carlos III RD16-0019-0010
Note:	Altres ajuts: This research was funded by grants 158/U/2017 from Fundacio La Marato TV3 and from the Instituto de Salud Carlos III (co-financed by the European Regional Development Fund). P.C.R. and E.J.X. are members of RETICS INVICTUS PLUS . S.B. and N.P. aremembers of the Quality Research Group 2017-SGR-1149 from Generalitat de Catalunya, and they are members of the Spanish Atherosclerosis Society Vascular Biology Group.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Carotid atherosclerosis ; Ischemic stroke ; Atherothrombotic stroke ; Biomarkers ; Lipoproteins ; Lipids ; Inflammation ; Plaque vulnerability
Published in:	International journal of molecular sciences, Vol. 21 Núm. 21 (2020) , p. 8236, ISSN 1422-0067

DOI: 10.3390/ijms21218236
PMID: 33153204

26 p, 1.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
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