Switchless multiplexing of graphene active sensor arrays for brain mapping
Garcia Cortadella, Ramon (Institut Català de Nanociència i Nanotecnologia)
Schaefer, Nathan (Institut Català de Nanociència i Nanotecnologia)
Cisneros-Fernández, Jose (Institut de Microelectrònica de Barcelona)
Ré, Lucia (Institut de Microelectrònica de Barcelona)
Illa, Xavi (Institut de Microelectrònica de Barcelona)
Schwesig, Gerrit (Ludwig-Maximilians-Universität München. Faculty of Medicine)
Moya Lara, Ana (Institut de Microelectrònica de Barcelona)
Santiago, Sara (Universitat Autònoma de Barcelona. Departament de Química)
Guirado López, Gonzalo (Universitat Autònoma de Barcelona. Departament de Química)
Villa, Rosa (Institut de Microelectrònica de Barcelona)
Sirota, Anton (Ludwig-Maximilians-Universität München. Faculty of Medicine)
Serra Graells, Francesc (Institut de Microelectrònica de Barcelona)
Garrido, Jose (Institut Català de Nanociència i Nanotecnologia)
Guimerà Brunet, Anton (Institut de Microelectrònica de Barcelona)

Date:	2020
Abstract:	Sensor arrays used to detect electrophysiological signals from the brain are paramount in neuroscience. However, the number of sensors that can be interfaced with macroscopic data acquisition systems currently limits their bandwidth. This bottleneck originates in the fact that, typically, sensors are addressed individually, requiring a connection for each of them. Herein, we present the concept of frequency-division multiplexing (FDM) of neural signals by graphene sensors. We demonstrate the high performance of graphene transistors as mixers to perform amplitude modulation (AM) of neural signals in situ, which is used to transmit multiple signals through a shared metal line. This technology eliminates the need for switches, remarkably simplifying the technical complexity of state-of-the-art multiplexed neural probes. Besides, the scalability of FDM graphene neural probes has been thoroughly evaluated and their sensitivity demonstrated in vivo. Using this technology, we envision a new generation of high-count conformal neural probes for high bandwidth brain machine interfaces.
Grants:	European Commission 732032 European Commission 881603 European Commission 785219 Ministerio de Ciencia e Innovación SEV-2017-0706 Ministerio de Ciencia e Innovación FIS2017-85787-R Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1426
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió sotmesa a revisió
Subject:	Multiplexing ; Graphene ; Active sensors ; Bioelectronics ; Neural sensing
Published in:	Nano letters, Vol. 20, issue 5 (May 2020) , p. 3528-3537, ISSN 1530-6992

DOI: 10.1021/acs.nanolett.0c00467
PMID: 32223249

Preprint 28 p, 1.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Group in Electrochemistry, Photochemistry and Organic Reactivity (GEFRO)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles