Nanomaterials for nanotheranostics : tuning their properties according to disease needs
Wong, Xin Yi (Institut Català de Nanociència i Nanotecnologia)
Sena-Torralba, Amadeo (Institut Català de Nanociència i Nanotecnologia)
Álvarez Diduk, Ruslan (Institut Català de Nanociència i Nanotecnologia)
Muthoosamy, Kasturi (University of Nottingham Malaysia. Centre of Nanotechnology and Advanced Materials)
Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia)

Fecha:	2020
Resumen:	Nanotheranostics is one of the biggest scientific breakthroughs in nanomedicine. Most of the currently available diagnosis and therapies are invasive, time-consuming, and associated with severe toxic side effects. Nanotheranostics, on the other hand, has the potential to bridge this gap by harnessing the capabilities of nanotechnology and nanomaterials for combined therapeutics and diagnostics with markedly enhanced efficacy. However, nanomaterial applications in nanotheranostics are still in its infancy. This is due to the fact that each disease has a particular microenvironment with well-defined characteristics, which promotes deeper selection criteria of nanomaterials to meet the disease needs. In this review, we have outlined how nanomaterials are designed and tailored for nanotheranostics of cancer and other diseases such as neurodegenerative, autoimmune (particularly on rheumatoid arthritis), and cardiovascular diseases. The penetrability and retention of a nanomaterial in the biological system, the therapeutic strategy used, and the imaging mode selected are some of the aspects discussed for each disease. The specific properties of the nanomaterials in terms of feasibility, physicochemical challenges, progress in clinical trials, its toxicity, and their future application on translational medicine are addressed. Our review meticulously and critically examines the applications of nanotheranostics with various nanomaterials, including graphene, across several diseases, offering a broader perspective of this emerging field.
Ayudas:	Ministerio de Economía y Competitividad SEV2201320295 Agencia Estatal de Investigación MAT2017-87202-P
Nota:	Altres ajuts: this work was funded by the CERCA Program/Generalitat de Catalunya.
Derechos:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió acceptada per publicar
Materia:	Nanotheranostics ; Nanomaterials ; Cancer ; Solid tumor ; Liquid tumor ; Neurodegenerative diseases ; Autoimmune diseases ; Cardiovascular diseases ; Clinical trials ; Graphene
Publicado en:	ACS nano, Vol. 14, issue 3 (March 2020) , p. 2585-2627, ISSN 1936-086X

DOI: 10.1021/acsnano.9b08133

Postprint 159 p, 3.7 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Nanociència i Nanotecnologia (ICN2)
Artículos > Artículos de investigación
Artículos > Artículos publicados