On an SE(Is)(Ih)AR epidemic model with combined vaccination and antiviral controls for COVID-19 pandemic
De la Sen, Manuel (Institute of Research and Development of Processes IIDP)
Ibeas, Asier (Universitat Autònoma de Barcelona. Departament de Telecomunicació i Enginyeria de Sistemes)

Data:	2021
Resum:	In this paper, we study the nonnegativity and stability properties of the solutions of a newly proposed extended SEIR epidemic model, the so-called SE(Is)(Ih)AR epidemic model which might be of potential interest in the characterization and control of the COVID-19 pandemic evolution. The proposed model incorporates both asymptomatic infectious and hospitalized infectious subpopulations to the standard infectious subpopulation of the classical SEIR model. In parallel, it also incorporates feedback vaccination and antiviral treatment controls. The exposed subpopulation has three different transitions to the three kinds of infectious subpopulations under eventually different proportionality parameters. The existence of a unique disease-free equilibrium point and a unique endemic one is proved together with the calculation of their explicit components. Their local asymptotic stability properties and the attainability of the endemic equilibrium point are investigated based on the next generation matrix properties, the value of the basic reproduction number, and nonnegativity properties of the solution and its equilibrium states. The reproduction numbers in the presence of one or both controls is linked to the control-free reproduction number to emphasize that such a number decreases with the control gains. We also prove that, depending on the value of the basic reproduction number, only one of them is a global asymptotic attractor and that the solution has no limit cycles.
Ajuts:	Agencia Estatal de Investigación RTI2018-094336-B-I00
Nota:	Altres ajuts: Instituto de Salud Carlos III (COV 20/01213)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	SEIR epidemic model ; SE(Is)(Ih)AR epidemic model ; Vaccination control ; Antiviral treatment control ; Reproduction number ; Nonnegativity of solutions ; Limit cycles
Publicat a:	Advances in difference equations, Vol. 2021 (February 2021) , art. 92, ISSN 1687-1847

DOI: 10.1186/s13662-021-03248-5
PMID: 33552151

30 p, 2.3 MB

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