The genomics of ecological flexibility, large brains,and long lives in capuchin monkeys revealedwith fecalFACS
Orkin, Joseph (University of Calgary. Department of Anthropology and Archaeology)
Montague, Michael (University of Pennsylvania. Department of Neuroscience)
Tejada-Martinez, Daniela (Thomas Jefferson University. Department of Biochemistry and Molecular Biology)
de Manuel, Marc (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
del Campo, Javier (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Cheves Hernandez, Saul (Área de Concervación Guanacaste)
Di Fiore, Anthony (University of Texas at Austin. Department of Anthropology and Primate Molecular Ecology and Evolution Laboratory)
Fontsere, Claudia (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Hodgson, Jason A. (Pennsylvania State University. Department of Anthropology)
Janiak, Mareike (University of Calgary. Department of Anthropology and Archaeology)
Kuderna, Lukas (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Lizano, Esther (Institut Català de Paleontologia Miquel Crusafont)
Martino, Maria Pia (Kids Saving the Rainforest Wildlife Rescue Center)
Niimura, Yoshihito (The University of Tokyo. Department of Applied Biological Chemistry)
Perry, George (Pennsylvania State University. Department of Anthropology)
Soto Valverde, Carmen (Kids Saving the Rainforest Wildlife Rescue Center)
Tanga, Jia (University of Calgary. Department of Anthropology and Archaeology)
Warren, Wesley (University of Missouri. Division of Animal Sciences, School of Medicine)
de Magalhaes, Joao Pedro (University of Liverpool. Institute of Ageing and Chronic Disease)
Kawamura, Shoji (The University of Tokyo. Department of Integrated Biosciences)
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont)
Krawetz, Roman (University of Calgary. Department of Cell Biology and Anatomy)
Melin, Amanda D. (University of Calgary. Department of Anthropology and Archaeology)

Data:	2021
Resum:	Ecological flexibility, extended lifespans, and large brains have long intrigued evolutionary biologists, and comparative genomics offers an efficient and effective tool for generating new insights into the evolution of such traits. Studies of capuchin monkeys are particularly well situated to shed light on the selective pressures and genetic underpinnings of local adaptation to diverse habitats, longevity, and brain development. Distributed widely across Central and South America, they are inventive and extractive foragers, known for their sensorimotor intelligence. Capuchins have among the largest relative brain size of any monkey and a lifespan that exceeds 50 y, despite their small (3 to 5 kg) body size. We assemble and annotate a de novo reference genome for Cebus imitator Through high-depth sequencing of DNA derived from blood, various tissues, and feces via fluorescence-activated cell sorting (fecalFACS) to isolate monkey epithelial cells, we compared genomes of capuchin populations from tropical dry forests and lowland rainforests and identified population divergence in genes involved in water balance, kidney function, and metabolism. Through a comparative genomics approach spanning a wide diversity of mammals, we identified genes under positive selection associated with longevity and brain development. Additionally, we provide a technological advancement in the use of noninvasive genomics for studies of free-ranging mammals. Our intra- and interspecific comparative study of capuchin genomics provides insights into processes underlying local adaptation to diverse and physiologically challenging environments, as well as the molecular basis of brain evolution and longevity.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/BP-00265 European Commission 864203 Ministerio de Economía y Competitividad BFU2017-86471-P Ministerio de Ciencia e Innovación CEX2018-000792-M Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-880 Ministerio de Economía y Competitividad CGL2017-82654-P
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Brain size ; Flow cytometry ; Longevity ; Noninvasive genomics ; Seasonality
Publicat a:	Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 7 (February 2021) , e2010632118, ISSN 1091-6490

DOI: 10.1073/pnas.2010632118
PMID: 33574059

12 p, 2.8 MB

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