Cell death in plant immunity
Pitsili, Eugenia (Centre de Recerca en Agrigenòmica)
Phukan, Ujjal J. (Centre de Recerca en Agrigenòmica)
Sánchez Coll, Núria (Centre de Recerca en Agrigenòmica)

Date:	2020
Abstract:	Pathogen recognition by the plant immune system leads to defense responses that are often accompanied by a form of regulated cell death known as the hypersensitive response (HR). HR shares some features with regulated necrosis observed in animals. Genetically, HR can be uncoupled from local defense responses at the site of infection and its role in immunity may be to activate systemic responses in distal parts of the organism. Recent advances in the field reveal conserved cell death-specific signaling modules that are assembled by immune receptors in response to pathogen-derived effectors. The structural elucidation of the plant resistosome - an inflammasome-like structure that may attach to the plasma membrane upon activation - opens the possibility that HR cell death is mediated by the formation of pores at the plasma membrane. Necrotrophic pathogens that feed on dead tissue have evolved strategies to trigger HR cell death pathway as a survival strategy. Ectopic activation of immunomodulators during autoimmune reactions can also promote HR cell death. In this perspective, we discuss the role and regulation of HR in these different contexts.
Grants:	Ministerio de Economía y Competitividad RyC2014-16158 Ministerio de Economía y Competitividad AGL2016-78002-R Ministerio de Economía y Competitividad SEV-2015-0533
Note:	Altres ajuts: CERCA Programme/Generalitat de Catalunya
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article de revisió ; Article ; Versió acceptada per publicar
Subject:	Plant ; Pathogen ; Immunity ; Defense ; Cell death ; Hypersensitive response
Published in:	Cold Spring Harbor Perspectives in Biology, Vol. 12, issue 6 (June 2020) , art. a036483, ISSN 1943-0264

DOI: 10.1101/cshperspect.a036483
PMID: 31615784

Postprint 23 p, 1.6 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > CRAG (Centre for Research in Agricultural Genomics)
Articles > Published articles