Specific Susceptibility to COVID-19 in Adults with Down Syndrome
Illouz, Tomer (Bar-Ilan University. The Paul Feder Laboratory On Alzheimer's Disease Research)
Biragyn, Arya (NIA. Laboratory of Molecular Biology and Immunology)
Frenkel-Morgenstern, Milana (Bar-Ilan University. Cancer Genomics and BioComputing of Complex Diseases Lab, Azrieli Faculty of Medicine)
Weissberg, Orly (Bar-Ilan University. Cancer Genomics and BioComputing of Complex Diseases Lab, Azrieli Faculty of Medicine)
Gorohovski, Alessandro (Bar-Ilan University. Cancer Genomics and BioComputing of Complex Diseases Lab, Azrieli Faculty of Medicine)
Merzon, Eugene (Tel Aviv University. Sackler School of Medicine)
Green, Ilan (Tel Aviv University. Sackler School of Medicine)
Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau)
Flores-Aguilar, Lisi (McGill University. Department of Anatomy and Cell Biology)
del Mar Dierssen Sotos, Maria (Centro de Investigación Biomédica en Red de Enfermedades Raras)
De Toma, Ilario (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Lifshitz, Hefziba (Bar-Ilan University. School of Education)
Antonarakis, Stylianos E. (iGE3 Institute of Genetics and Genomics of Geneva, 1211 Geneva, Switzerland)
Yu, Eugene (State University of New York At Buffalo. Genetics, Genomics and Bioinformatics Program)
Herault, Yann (IGBMC-UMR. Université de Strasbourg, CNRS, INSERM, Institut de Génétique Biologie Moléculaire Et Cellulaire)
Potier, Marie-Claude (Institut du Cerveau et de la Moëlle épinière (París, França))
Botté, Alexandra (Institut du Cerveau et de la Moëlle épinière (París, França))
Roper, Randall (Indiana University-Purdue University Indianapolis. Department of Biology)
Sredni, Benjamin (Bar-Ilan University. The Mina and Everard Goodman Faculty of Life Sciences)
Sarid, Ronit (Bar-Ilan University. The Mina and Everard Goodman Faculty of Life Sciences)
London, Jacqueline (CNRS. Université de Paris, BFA, UMR 8251)
Mobley, William (University of California. Department of Neurosciences)
Strydom, Andre (South London and Maudsley NHS Foundation Trust)
Okun, Eitan (Bar-Ilan University. The Mina and Everard Goodman Faculty of Life Sciences)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer's disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	COVID-19 ; Down syndrome ; Immune dysregulation ; SARS-CoV-2 ; Vaccine
Publicado en:	Neuromolecular medicine, march 2021, p. 1-11, ISSN 1559-1174

Erratum: https://ddd.uab.cat/record/255549
DOI: 10.1007/s12017-021-08651-5
PMID: 33660221

11 p, 935.0 KB

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