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| Home > Articles > Published articles > Long-Term Outcomes of Patients With Cocaine Use Disorder : |
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)| Date: | 2021 |
| Abstract: | Objective: Cocaine Use Disorder (CUD) has been associated with multiple complications and premature death. The purpose of the present study was to analyze the relationship between baseline medical comorbidity and long-term medical outcomes (i. e. , hospitalization, death) in a cohort of patients primarily admitted for detoxification. In addition, we aimed to analyze cause-specific mortality. Methods: longitudinal study in CUD patients admitted for detoxification between 2001 and 2018. Substance use characteristics, laboratory parameters and medical comorbidity by VACS Index were assessed at admission. Follow-up and health-related outcomes were ascertained through visits and e-health records. Kaplan-Meier and Cox regression models were used to analyze survival and predictors of hospitalization and death. Results: 175 patients (77. 7% men) were included. Age at admission was 35 years [IQR: 30-41 years], 59. 4% of the patients being intranasal users, 33. 5% injectors, and 7. 1% smokers. Almost 23% of patients had concomitant alcohol use disorder, 39% were cannabis users and 9% opiate users. The median VACS Index score on admission was 10 points [IQR: 0-22]. After 12 years [IQR: 8. 6-15 years] of follow-up there were 1,292 (80. 7%) ED admissions and 308 (19. 3%) hospitalizations. The incidence rate of ED admission and hospitalization was 18. 6 × 100 p-y (95% CI: 15. 8-21. 8 × 100 p-y). Mortality rate was 1. 4 × 100 p-y (95% CI: 0. 9-2. 0 × 100 p-y) and, baseline comorbidity predicted hospitalization and mortality: those with VACS Index >40 were 3. 5 times (HR:3. 52, 95% CI: 1. 19-10. 4) more likely to dye with respect to patients with VACS < 20. Conclusion: addiction care warrants optimal stratification of medical comorbidity to improve health outcomes and survival of CUD patients seeking treatment of the disorder. |
| Grants: | Instituto de Salud Carlos III RD16-0017-0003 Instituto de Salud Carlos III PI17-00174 Instituto de Salud Carlos III PI20-00883 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR316 Instituto de Salud Carlos III INT19-00026 Instituto de Salud Carlos III JR20-00016 |
| Note: | Altres ajuts: National Plan on Drugs (PNSD), Spain (grant number 2018/020 and 2020/024); the Agency for Management of University and Research Grants, Government of Catalonia (grant number |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Cocaine use disorder ; VACS index ; Comorbidity ; Mortality ; Hospitalization |
| Published in: | Frontiers in Pharmacology, Vol. 12 (february 2021) , ISSN 1663-9812 |
