Coordination polymers nanoparticles for bioimaging
Suárez García, Salvio (Institut Català de Nanociència i Nanotecnologia)
Solorzano Rodriguez, Ruben (Institut Català de Nanociència i Nanotecnologia)
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química)
Alibes, Ramón (Universitat Autònoma de Barcelona. Departament de Química)
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química)
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)

Date:	2021
Abstract:	Early diagnosis of patient diseases is subjected to the appropriate use of bioimaging techniques. For this reason, the development of contrast agents that improve and enhance the response of current clinical imaging practices is a pressing concern. Non-invasive bioimaging techniques most often need specific probes to follow and measure biological routes in living systems. These molecular imaging agents must exhibit: I) a remarkable contrast effect, i. e. a high signal-to-noise ratio under real physiological conditions, II) pronounced in vivo stability under the effect of numerous enzymes or proteases present in serum or targeted tissue equilibrated with a fast clearance from healthy organs and III) low cost and eco-friendly production. To overcome current drawbacks that hindrance the full development of the different bioimaging techniques, several groups are exploring nanoparticles as contrast agents. In this scenario, coordination polymer nanoparticles have emerged as a handy platform offering predesigned unique advantages thanks to their chemical flexibility, structural diversity and tailoring skills. Indeed, these systems reveal high metal cargos, low toxicity and multifunctional character by adequately selecting the combination of metal ions and ligands. Moreover, in a reminiscent way of organic polymeric nanoparticles, coordination polymer nanoparticles have also demonstrated its ability to encapsulate therapeutic-active molecules, thus combining diagnostic and therapeutic functionalities, the so-called Theranostic nanomedicine. For all these reasons, the use of this family of nanoparticles as imaging contrast agents has attracted broad interest over the last years with numerous examples being reported. Herein, we review main accomplishments in the area grouped according to the used technology, including magnetic resonance imaging, computed tomography, optical imaging, radioimaging or photoacoustic imaging.
Grants:	Agencia Estatal de Investigación RTI2018-098027-B-C21 Agencia Estatal de Investigación CTQ2016-75363-R Ministerio de Economía y Competitividad SEV-2017-0706 Ministerio de Economía y Competitividad BES-2015-071492 Ministerio de Educación, Cultura y Deporte FPU14/03170
Note:	Altres ajuts: the ICN2 is funded by the CERCA programme/Generalitat de Catalunya.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Bioimaging ; Contrast agent ; Nanoparticle ; Coordination polymer ; Theranostic
Published in:	Coordination chemistry reviews, Vol. 432 (April 2021) , art. 213716, ISSN 0010-8545

DOI: 10.1016/j.ccr.2020.213716

Postprint 61 p, 39.8 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Synthesis of Bioactive Organic Compounds and Functional Materials (SynOrgFUN)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles