Epithelial-Mesenchymal Transition in the Resistance to Somatostatin Receptor Ligands in Acromegaly
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Jordà, Mireia (Institut Germans Trias i Pujol)
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Date: |
2021 |
Abstract: |
Epithelial-mesenchymal transition (EMT) is a dynamic process by which epithelial cells loss their phenotype and acquire mesenchymal traits, including increased migratory and invasive capacities. EMT is involved in physiological processes, such as embryogenesis and wound healing, and in pathological processes such as cancer, playing a pivotal role in tumor progression and metastasis. Pituitary tumors, although typically benign, can be locally invasive. Different studies have shown the association of EMT with increased tumor size and invasion in pituitary tumors, and in particular with a poor response to Somatostatin Receptor Ligands (SRLs) treatment in GH-producing pituitary tumors, the main cause of acromegaly. This review will summarize the current knowledge regarding EMT and SRLs resistance in acromegaly and, based on this relation, will suggest new biomarkers and possible therapies to SRLs resistant tumors. |
Grants: |
Instituto de Salud Carlos III PM15-00027
|
Rights: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Subject: |
Epithelial-menchymal transition ;
Somatostatin analogs ;
Pituitary ;
E-cadherin ;
Somatotroph adenoma ;
Growth hormone ;
PitNETs ;
Endocrine tumors |
Published in: |
Frontiers in endocrinology, Vol. 12 (march 2021) , ISSN 1664-2392 |
DOI: 10.3389/fendo.2021.646210
PMID: 33790868
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Record created 2021-04-05, last modified 2024-05-06