Bilateral Macular Hole Related to Tamoxifen Low-Dose Toxicity
Torrell Belzach, Nuria (Institut d'Investigació Biomèdica Sant Pau)
Vela Segarra, José Ignacio (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Crespí, Jaume (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Alhayek, Mohammed (Institut d'Investigació Biomèdica Sant Pau)

Date:	2020
Abstract:	Bilateral macular hole is a rare secondary effect of tamoxifen, a condition which is probably underdiagnosed. We describe the case of a 63-year-old woman who had received low-dose treatment with tamoxifen for 10 years. She presented with a best-corrected visual acuity of 20/40 in both eyes and bilateral macular hole with posterior hyaloid attachment. No reflective deposits were observed. A 23-gauge pars plana vitrectomy with internal limiting membrane peeling and gas tamponade was performed in the right eye with no anatomical or functional improvement. The most accepted mechanism of macular hole related to tamoxifen is Müller cell toxicity with retinal tissue loss. Therefore, it seems that the standard procedure used in idiopathic macular hole is not the optimal choice, due to a different pathogenic mechanism.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Macular hole ; Vitrectomy ; Tamoxifen ; Retinal toxicity
Published in:	Case Reports in Ophthalmology, Vol. 11 (october 2020) , p. 528-533, ISSN 1663-2699

DOI: 10.1159/000508327
PMID: 33173501

6 p, 311.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles