Opportunities of Bacterial Cellulose to Treat Epithelial Tissues
Anton-Sales, Irene (Institut de Ciència de Materials de Barcelona)
Beekmann, Uwe (Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Friedrich Schiller University Jena, 07743 Jena, Germany.)
Laromaine, Anna (Institut de Ciència de Materials de Barcelona)
Roig i Serra, Anna (Institut de Ciència de Materials de Barcelona)
Kralisch, Dana (Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Friedrich Schiller University Jena, 07743 Jena, Germany.)
Universitat Autònoma de Barcelona

Data:	2019
Resum:	In this mini-review, we highlight the potential of the biopolymer bacterial cellulose to treat damaged epithelial tissues. Epithelial tissues are cell sheets that delimitate both the external body surfaces and the internal cavities and organs. Epithelia serve as physical protection to underlying organs, regulate the diffusion of molecules and ions, secrete substances and filtrate body fluids, among other vital functions. Because of their continuous exposure to environmental stressors, damage to epithelial tissues is highly prevalent. Here, we first compare the properties of bacterial cellulose to the current gold standard, collagen, and then we examine the use of bacterial cellulose patches to heal specific epithelial tissues; the outer skin, the ocular surface, the oral mucosa and other epithelial surfaces. Special emphasis is made on the dermis since, to date, this is the most widespread medical use of bacterial cellulose. It is important to note that some epithelial tissues represent only the outermost layer of more complex structures such as the skin or the cornea. In these situations, depending on the penetration of the lesion, bacterial cellulose might also be involved in the regeneration of, for instance, inner connective tissue.
Ajuts:	European Commission 675743 European Commission 777682
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; Article ; Versió publicada
Matèria:	Biomaterials ; Bacterial cellulose ; Epithelial tissues ; Wound dressing ; Cell carrier ; Drug delivery ; Epithelial regeneration
Publicat a:	Current Drug Targets, Vol. 20 (june 2019) , p. 808-822, ISSN 1873-5592

DOI: 10.2174/1389450120666181129092144
PMID: 30488795

15 p, 2.6 MB

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