The Role of Photoprotection in Optimizing the Treatment of Atopic Dermatitis
Piquero-Casals, Jaime (Dermik. Multidisciplinary Dermatology Clinic)
Carrascosa, José Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Morgado-Carrasco, Daniel (Hospital Clínic i Provincial de Barcelona)
Narda, Mridvika (ISDIN. Innovation and Development)
Trullas, Carles (ISDIN. Innovation and Development)
Granger, Corinne (ISDIN. Innovation and Development)
Fabbrocini, Gabriella (University of Naples Federico II. Department of Clinical Medicine and Surgery)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Atopic dermatitis (AD) is a chronic inflammatory skin disease with an estimated prevalence of 10-15% in children and 2-10% in adults. Clinically, there is notable phenotypic variability driven by a complex interaction between genetics, immune function, and the environment. Impairment of the skin barrier plays a significant role in the pathogenesis of AD. The apparent beneficial effect of sunlight in patients with atopic eczema is questioned due to its capacity to disrupt the skin barrier and generate free radicals that can damage proteins, lipids, and DNA. The sum of the external factors that an individual is exposed to throughout their lifetime is termed the exposome. Environmental factors such as sun exposure, temperature, and humidity contribute to both AD flares and regional prevalence variation. Literature on photoprotection in atopic dermatitis is very scarce. The use of adequate sunscreens in atopic dermatitis can ensure the level of photoprotection required to prevent skin photoaging and skin cancer and to mitigate skin barrier dysfunction, decrease inflammation, and neutralize facial redness. Herein we discuss and review the role of UV radiation and the exposome in the etiology of AD, as well as the role of adequate photoprotection.
Note:	Funding: The journal's Rapid Service Fee was supported by ISDIN.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Atopic dermatitis ; Eczema ; Exposome ; Nonpharmacologic ; Photoprotection ; Skin barrier ; Sunscreens ; Ultraviolet radiation
Published in:	Dermatology and Therapy, Vol. 11 (february 2021) , p. 315-325, ISSN 2190-9172

DOI: 10.1007/s13555-021-00495-y
PMID: 33582977

11 p, 532.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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Articles > Published articles