Bone Fragility Fractures in CKD Patients
Pimentel, Ana (AURA Paris-Nord, Saint-Ouen, France)
Ureña-Torres, Pablo (Necker Hospital, University of Paris Descartes, Department of Renal Physiology, Paris, France)
Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Fernandez-Martín, José Luis (Instituto de Investigación Sanitaria del Principado de Asturias)
Cohen-Solal, Martine (Hôpital Lariboisière)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Chronic kidney diseases (CKD) are associated with mineral and bone diseases (MBD), including pain, bone loss, and fractures. Bone fragility related to CKD includes the risk factors observed in osteoporosis in addition to those related to CKD, resulting in a higher risk of mortality related to fractures. Unawareness of such complications led to a poor management of fractures and a lack of preventive approaches. The current guidelines of the Kidney Disease Improving Global Outcomes (KDIGO) recommend the assessment of bone mineral density if results will impact treatment decision. In addition to bone density, circulating biomarkers of mineral, serum bone turnover markers, and imaging techniques are currently available to evaluate the fracture risk. The purpose of this review is to provide an overview of the epidemiology and pathogenesis of CKD-associated bone loss. The contribution of the current tools and other techniques in development are discussed. We here propose a current view of how to better predict bone fragility and the therapeutic options in CKD.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; Article ; Versió publicada
Subject:	Bone ; Fracture ; Bone mineral density ; CKD-MBD ; Phosphate ; Calcium ; Parathyroid hormone ; Imaging
Published in:	Calcified Tissue International, Vol. 108 (november 2020) , p. 539-550, ISSN 1432-0827

DOI: 10.1007/s00223-020-00779-z
PMID: 33219822

12 p, 868.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Published articles