Molecularly imprinted polymer-decorated magnetite nanoparticles for selective sulfonamide detection
Zamora Gálvez, Alejandro (Institut Català de Nanociència i Nanotecnologia)
Ait-Lahcen, Abdellatif (Institut Català de Nanociència i Nanotecnologia)
Mercante, Luiza A. (Institut Català de Nanociència i Nanotecnologia)
Morales-Narváez, Eden (Institut Català de Nanociència i Nanotecnologia)
Amine, Aziz (Université Hassan II. Faculté des Sciences et Techniques)
Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia)

Data:	2016
Resum:	Sulfonamides are known not only to be antimicrobial drugs that lead to antimicrobial resistance but also to be chemotherapeutic agents that may be allergenic and potentially carcinogenic, which represents a potentially hazardous compound once present in soil or water. Herein, a hybrid material based on molecularly imprinted polymer (MIP)-decorated magnetite nanoparticles for specific and label-free sulfonamide detection is reported. The composite has been characterized using different spectroscopic and imaging techniques. The magnetic properties of the composite are used to separate, preconcentrate, and manipulate the analyte which is selectively captured by the MIP onto the surface of the composite. Screen printed electrodes have been employed to monitor the impedance levels of the whole material, which is related to the amount of the captured analyte, via electrochemical impedance spectroscopy. This composite-based sensing system exhibits an extraordinary limit of detection of 1 × 10 mol L (2. 8 × 10 ppb) (S/N = 3), which is close to those obtained with liquid chromatography and mass spectrometry, and it was demonstrated to screen sulfamethoxazole in a complex matrix such as seawater, where according to the literature sulfonamides content is minimum compared with other environmental samples.
Ajuts:	European Commission 613844 Ministerio de Economía y Competitividad SEV-2013-0295 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-260
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Antimicrobial drug ; Antimicrobial resistances ; Chemotherapeutic agents ; Environmental sample ; Hazardous compounds ; Limit of detection ; Molecularly Imprinted Polymer ; Screen printed electrodes ; Electrochemical Techniques ; Magnetite Nanoparticles ; Molecular Imprinting ; Polymers ; Sulfonamides
Publicat a:	Analytical chemistry, Vol. 882, issue 7 (April 2016) , p. 3578-3584, ISSN 1520-6882

DOI: 10.1021/acs.analchem.5b04092

Postprint 8 p, 892.5 KB

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