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| Home > Articles > Published articles > Blood Biomarker Panels for the Early Prediction of Stroke-Associated Complications |
(Hospital Universitari Vall d'Hebron. Institut de Recerca) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Hospital de Tortosa Verge de la Cinta) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Instituto de Investigación Biomédica de A Coruña) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Hospital Universitari de Bellvitge) (Hospital Universitario Central de Asturias) (Hospital Universitari de Girona Doctor Josep Trueta) (Hospital Universitari Vall d'Hebron) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Hospital Universitari Vall d'Hebron. Institut de Recerca)| Date: | 2021 |
| Abstract: | Acute decompensated heart failure (ADHF) and respiratory tract infections (RTIs) are potentially life-threatening complications in patients experiencing stroke during hospitalization. We aimed to test whether blood biomarker panels might predict these complications early after admission. Nine hundred thirty-eight patients experiencing ischemic stroke were prospectively recruited in the Stroke-Chip study. Post-stroke complications during hospitalization were retrospectively evaluated. Blood samples were drawn within 6 hours after stroke onset, and 14 biomarkers were analyzed by immunoassays. Biomarker values were normalized using log-transformation and Z score. PanelomiX algorithm was used to select panels with the best accuracy for predicting ADHF and RTI. Logistic regression models were constructed with the clinical variables and the biomarker panels. The additional predictive value of the panels compared with the clinical model alone was evaluated by receiver operating characteristic curves. An internal validation through a 10-fold cross-validation with 3 repeats was performed. ADHF and RTI occurred in 19 (2%) and 86 (9. 1%) cases, respectively. Three-biomarker panels were developed as predictors: vascular adhesion protein-1. |
| Grants: | Ministerio de Economía y Competitividad DTS14/00004 Instituto de Salud Carlos III PI17/02130 European Commission. Horizon 2020 754517 Ministerio de Economía y Competitividad RD16/0019/0021 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | ADHF ; Biomarkers ; Stroke ; Stroke-associated infection ; Ischemic Stroke ; Prognosis |
| Published in: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 10 (february 2021) , ISSN 2047-9980 |
