Assessment of liver disease in patients with chronic hepatitis C and unhealthy alcohol use
Fuster, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
García Calvo, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Zuluaga Blanco, Yenny Paola (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bolao, Ferran (Institut d'Investigació Biomèdica de Bellvitge)
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Hepatitis C virus (HCV) infection and unhealthy alcohol use are major drivers of the burden of liver disease worldwide and commonly co-occur. Assessment of underlying liver damage is a cornerstone of the clinical care of patients with chronic HCV infection and/or unhealthy alcohol use because many of them are diagnosed at advanced stages of disease. Early diagnosis of liver disease before decompensated liver cirrhosis becomes established is essential for treatment with direct acting antivirals and/or abstinence from alcohol consumption, which are the main therapeutic approaches for clinical management. In this review, we discuss current knowledge around the use of non-invasive methods to assess liver disease, such as abdominal ultrasound, controlled attenuation parameter, transient elastography, magnetic resonance imaging, and indices based on serum markers of liver injury.
Grants:	Instituto de Salud Carlos III RD/0017/0003 Instituto de Salud Carlos III PI17/00174 Instituto de Salud Carlos III PI20/00883 Instituto de Salud Carlos III JR20/00016 Instituto de Salud Carlos III CD19/00019 Instituto de Salud Carlos III INT19/00026 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-316
Note:	Altres ajuts: National Plan on Drugs, Spain, No. 2018/020, and No. 2020/024.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Hepatitis C virus ; Alcohol ; Liver fibrosis ; Non-invasive methods ; Ultrasound ; Transient elastography
Published in:	World Journal of Gastroenterology, Vol. 27 Núm. 23 (june 2021) , p. 3223-3237, ISSN 2219-2840

DOI: 10.3748/wjg.v27.i23.3223
DOI: 10.3748/wjg.v27.i23.3223.
PMID: 34163107

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The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles