BMI and pneumonia outcomes in critically ill COVID-19 patients : an international multicenter study
Chetboun, Mikael (CHU Lille)
Raverdy, Violeta (CHU Lille)
Labreuche, Julien (Univ. Lille, CHU Lille)
Simonnet, Arthur (Hôpital Roger Salengro. Pôle de Réanimation. CHU Lille)
Wallet, Florent (Centre International de Recherche en Infectiologie. Laboratoire des Pathogènes Emergents-Fondation Mérieux)
Caussy, Cyrielle (Université Claude Bernard Lyon 1. INSA Lyon. INRA. INSERM. CarMen Laboratory. Univ Lyon)
Antonelli, Massimo (Fondazione Policlinico Universitario A. Gemelli IRCCS)
Artigas Raventós, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Gomà, Gemma (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Meziani, Ferhat (FMTS. Regenerative Nanomedicine (RNM). Inserm)
Helms, Julie (Université de Strasbourg (UNISTRA). FMTS. LabEx TRANSPLANTEX)
Mylonakis, Eleftherios (Rhode Island Hospital and The Miriam Hospital)
Levy, Mitchell M. (Warren Alpert Medical School of Brown University)
Kalligeros, Markos (Rhode Island Hospital and The Miriam Hospital)
Latronico, Nicola (Spedali Civili University Hospital)
Piva, Simone (Spedali Civili University Hospital)
Cerf, Charles (Medico-surgical ICU. Hôpital Foch)
Neuville, Mathilde (Medico-surgical ICU. Hôpital Foch)
Klouche, Kada (CNRS. INSERM. University of Montpellier. PhyMedExp)
Larcher, Romaric (CNRS. INSERM. University of Montpellier. PhyMedExp)
Tamion, Fabienne (Normandie Univ)
Occhiali, Emilie (Rouen University Hospital (França))
Snacken, Morgane (Université Libre de Bruxelles)
Preiser, Jean-Charles (Université Libre de Bruxelles)
Kontar, Loay (Medical ICU Amiens University Hospital)
Riviere, Antoine (Intensive Care Unit. Abbeville General Hospital)
Silva, Stein (ToNIC, Toulouse NeuroImaging Center. Paul Sabatier University)
Sarton, Benjamine (ToNIC, Toulouse NeuroImaging Center. Paul Sabatier University)
Krouchi, Raphael (Centre hospitalier de Dunkerque)
Dubar, Victoria (Centre hospitalier de Dunkerque)
Palaiodimos, Leonidas (Albert Einstein College of Medicine. Montefiore Medical Center)
Karamanis, Dimitrios (University of Piraeus, Piraeus)
Perche, Juliette (Réanimation Polyvalente. Centre Hospitalier de Roubaix)
L'her, Erwan (Université de Bretagne Occidentale)
Busetto, Luca (University of Padova)
Dicker, Dror (Tel Aviv University)
Lev, Shaul (Hasharon Hospital-Rabin Medical Center)
Duhamel, Alain (Univ. Lille, CHU Lille)
Jourdain, Mercè (Hôpital Roger Salengro. Pôle de Réanimation. CHU Lille)
Pattou, François (CHU Lille)

Date:	2021
Abstract:	Previous studies unveiled a relation between the severity of COVID-19 pneumonia and obesity. The aims of this multicenter retrospective cohort study were to disentangle the association of BMI and associated metabolic risk factors (diabetes, hypertension, hyperlipidemia, current smoking) in critically ill patients with COVID-19. This multicenter retrospective cohort study enrolled patients admitted in intensive care for COVID-19, in 21 centers (Europe, Israel, USA) between 02/19/2020 and 05/19/2020. Primary and secondary outcomes were the need for invasive mechanical ventilation (IMV), and 28-day mortality. A total of 1,461 patients were enrolled, median(IQR) age was 64 years (40. 9-72. 0); 73. 2% males; BMI 28. 1 kg/m 2 (25. 4-32. 3); 1,080 patients (73. 9%) required IMV; the 28-day mortality estimate was 36. 1% (95%CI, 33. 0-39. 5). Adjusted mixed logistic regression model showed a significant linear relation between BMI and IMV: OR 1. 27 (95%CI, 1. 12-1. 45) per 5 kg/m 2. Adjusted Cox proportional hazards regression model showed a significant association between BMI and mortality, which was only increased in obesity class III (≥40 kg/m 2) (HR 1. 68 (95%CI 1. 06-2. 64). In critically ill COVID-19 patients, we observed a linear association between BMI and the need for IMV, independent of other metabolic risk factors, and a non-linear association between BMI and mortality risk. (NCT04391738).
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	COVID-19 ; Obesity ; Critical Care ; Risk Factors ; Prevention
Published in:	Obesity (Silver Spring, Md.), may 2021, ISSN 1930-739X

DOI: 10.1002/oby.23223
PMID: 33966355

37 p, 17.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles