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14 p, 1.9 MB |
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients : a randomised controlled trial
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Chastre, Jean (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
François, Bruno (Réanimation Polyvalente and Inserm CIC 1435 & UMR 1092. CHU) ;
Bourgeois, Marc (AZ Sint-Jan Brugge-Oostende AV) ;
Komnos, Apostolos (General Hospital of Larissa) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
Rahav, Galia (Chaim Sheba Medical Center. Sackler School of Medicine. Tel Aviv University) ;
De Schryver, Nicolas (Clinique Saint-Pierre) ;
Lepape, Alain (Hospices Civils de Lyon Hôpital Lyon Sud) ;
Koksal, Iftihar (Faculty of Medicine. Trabzon and Acibadem University Faculty of Medicine. Karadeniz Technical University) ;
Luyt, Charles-Edouard (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
Sánchez-García, Miguel (Hospital Clínico San Carlos. Unidad de Cuidados Intensivos) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona. Servei de Pneumologia) ;
Eggimann, Philippe (Department of Locomotor Apparatus. Centre Hospitalier Universitaire Vaudois CHUV) ;
Koulenti, Despoina (2nd Critical Care Department. Attikon University Hospital. National and Kapodistrian. University of Athens) ;
Holland, Thomas L. (Duke Clinical Research Institute) ;
Ali, Omar (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Shoemaker, Kathryn (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Ren, Pin (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Sauser, Julien (Infection Control Program. Faculty of Medicine. Geneva University Hospitals) ;
Ruzin, Alexey (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Tabor, David E. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Akhgar, Ahmad (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Wu, Yuling (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Jiang, Yu (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
DiGiandomenico, Antonio (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Colbert, Susan (Oncology. US SM&M. AstraZeneca) ;
Vandamme, Drieke (Inserm CIC 1435. CHU) ;
Coenjaerts, Frank (University Medical Center Utrecht) ;
Malhotra-Kumar, Surbhi (University of Antwerp. Laboratory of Medical Microbiology) ;
Timbermont, Leen (University of Antwerp. Laboratory of Medical Microbiology) ;
Oliver, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Barraud, Olivier (INSERM U1092. Centre Hospitalier Universitaire de Limoges. Université Limoges) ;
Bellamy, Terramika (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Bonten, Marc (Julius Center for Health Science and Primary Care. University Medical Center Utrecht. Utrecht University) ;
Goossens, Herman (Laboratory of Medical Microbiology. Vaccine and Infectious Disease Institute. University of Antwerp) ;
Reisner, Colin (DevPro Biopharma) ;
Esser, Mark T. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Jafri, Hasan S. (Late-Stage Development. Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Joannidis, Michael ;
Klimscha, Walter ;
De Waele, Elisabeth ;
Devriendt, Jacques ;
Huberlant, Vincent ;
Depuydt, Pieter ;
Van Boxstael, Sam ;
Peric, Mladen ;
Kopic, Jasminka ;
Hanauer, Michal ;
Hruby, Tomas ;
Sramek, Vladimir ;
Svoboda, Petr ;
Vymazal, Tomas ;
Novacek, Martin ;
Annane, Djillali ;
Mira, Jean-Paul ;
Souweine, Bertrand ;
Dequin, Pierre-François ;
Meziani, Ferhat ;
Stephan, François ;
Nseir, Saad ;
Gibot, Sebastien ;
Schwebel, Carole ;
Plantefeve, Gaetan ;
Diehl, Jean-Luc ;
Richard, Christian ;
Lamer, Christian ;
Klouche, Kada ;
Jaber, Samir ;
Zakynthinos, Epaminondas ;
Filntisis, Georgios ;
Zakynthinos, Spyros ;
Koutsoukou, Antonia ;
Saroglou, Georgios ;
Nikolaou, Charikleia ;
Vlachogianni, Glykeria ;
Pnevmatikos, Ioannis ;
Mandragos, Konstantinos ;
Kremer, Ildiko ;
Rozgonyi, Zsolt Dezso ;
Marjanek, Zsuzsa ;
Martin-Loeches, Ignacio ;
Singer, Pierre ;
Van Heerden, Vernon ;
Carmeli, Yehuda ;
Povoa, Pedro ;
AlvarezSeoane, Antonio ;
Moura, Pedro ;
Gonzalez, Filipe ;
Ramirez, Paula ;
Torres Marti, Antonio ;
Ferrer Roca, Ricard ;
Oteiza, Lorena ;
Escudero, Dolores ;
Piacentini, Enrique ;
Vera-Artazcoz, Paula (Institut d'Investigació Biomèdica Sant Pau) ;
Tamayo, Luis ;
Gonzalez Gallego, Miguel Angel ;
Suberviola Canas, Borja ;
Figueira, Iglesias ;
Leon, Rafael ;
Korten, Volkan ;
Akova, Murat ;
Wyncoll, Duncan ;
Whitehouse, Tony ;
Hopkins, Phil ;
Sim, Malcolm ;
Golan, Yoav ;
Zervos, Marcus ;
Vazquez, Jose ;
Cherabuddi, Kartikeya ;
Smulian, George ;
Rouphael, Nadine ;
Welker, James ;
Sims, Mathew ;
Van Duin, David ;
McCarthy, Todd ;
Polk, Christopher
Background: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. [...]
2022 -  10.1186/s13054-022-04204-9
Critical Care, Vol. 26 Núm. 1 (december 2022) , p. 355
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37 p, 17.5 MB |
BMI and pneumonia outcomes in critically ill COVID-19 patients : an international multicenter study
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Chetboun, Mikael (CHU Lille) ;
Raverdy, Violeta (CHU Lille) ;
Labreuche, Julien (Univ. Lille, CHU Lille) ;
Simonnet, Arthur (Hôpital Roger Salengro. Pôle de Réanimation. CHU Lille) ;
Wallet, Florent (Centre International de Recherche en Infectiologie. Laboratoire des Pathogènes Emergents-Fondation Mérieux) ;
Caussy, Cyrielle (Université Claude Bernard Lyon 1. INSA Lyon. INRA. INSERM. CarMen Laboratory. Univ Lyon) ;
Antonelli, Massimo (Fondazione Policlinico Universitario A. Gemelli IRCCS) ;
Artigas Raventós, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Gomà, Gemma (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Meziani, Ferhat (FMTS. Regenerative Nanomedicine (RNM). Inserm) ;
Helms, Julie (Université de Strasbourg (UNISTRA). FMTS. LabEx TRANSPLANTEX) ;
Mylonakis, Eleftherios (Rhode Island Hospital and The Miriam Hospital) ;
Levy, Mitchell M. (Warren Alpert Medical School of Brown University) ;
Kalligeros, Markos (Rhode Island Hospital and The Miriam Hospital) ;
Latronico, Nicola (Spedali Civili University Hospital) ;
Piva, Simone (Spedali Civili University Hospital) ;
Cerf, Charles (Medico-surgical ICU. Hôpital Foch) ;
Neuville, Mathilde (Medico-surgical ICU. Hôpital Foch) ;
Klouche, Kada (CNRS. INSERM. University of Montpellier. PhyMedExp) ;
Larcher, Romaric (CNRS. INSERM. University of Montpellier. PhyMedExp) ;
Tamion, Fabienne (Normandie Univ) ;
Occhiali, Emilie (Rouen University Hospital (França)) ;
Snacken, Morgane (Université Libre de Bruxelles) ;
Preiser, Jean-Charles (Université Libre de Bruxelles) ;
Kontar, Loay (Medical ICU Amiens University Hospital) ;
Riviere, Antoine (Intensive Care Unit. Abbeville General Hospital) ;
Silva, Stein (ToNIC, Toulouse NeuroImaging Center. Paul Sabatier University) ;
Sarton, Benjamine (ToNIC, Toulouse NeuroImaging Center. Paul Sabatier University) ;
Krouchi, Raphael (Centre hospitalier de Dunkerque) ;
Dubar, Victoria (Centre hospitalier de Dunkerque) ;
Palaiodimos, Leonidas (Albert Einstein College of Medicine. Montefiore Medical Center) ;
Karamanis, Dimitrios (University of Piraeus, Piraeus) ;
Perche, Juliette (Réanimation Polyvalente. Centre Hospitalier de Roubaix) ;
L'her, Erwan (Université de Bretagne Occidentale) ;
Busetto, Luca (University of Padova) ;
Dicker, Dror (Tel Aviv University) ;
Lev, Shaul (Hasharon Hospital-Rabin Medical Center) ;
Duhamel, Alain (Univ. Lille, CHU Lille) ;
Jourdain, Mercè (Hôpital Roger Salengro. Pôle de Réanimation. CHU Lille) ;
Pattou, François (CHU Lille)
Previous studies unveiled a relation between the severity of COVID-19 pneumonia and obesity. The aims of this multicenter retrospective cohort study were to disentangle the association of BMI and associated metabolic risk factors (diabetes, hypertension, hyperlipidemia, current smoking) in critically ill patients with COVID-19. [...]
2021 - 10.1002/oby.23223
Obesity (Silver Spring, Md.), may 2021
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