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1.
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16 p, 5.1 MB |
MSIMEP : Predicting microsatellite instability from microarray DNA methylation tumor profiles
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Santamarina-García, Martín (University of Santiago de Compostela) ;
Brea-Iglesias, Jenifer (University of Santiago de Compostela) ;
Bramsen, Jesper Bertram (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Fuentes-Losada, Mar (University of Santiago de Compostela) ;
Caneiro-Gómez, Francisco Javier (University of Santiago de Compostela) ;
Vázquez-Bueno, Jose Ángel (Complejo Hospitalario Universitario de Ferrol) ;
Lázare-Iglesias, Hector (University of Santiago de Compostela) ;
Fernández-Díaz, Natalia (University of Santiago de Compostela) ;
Sánchez-Rivadulla, Laura (Complejo Hospitalario Universitario de Ferrol) ;
Betancor, Yoel Z. (University of Santiago de Compostela) ;
Ferreiro-Pantín, Miriam (University of Santiago de Compostela) ;
Conesa-Zamora, Pablo (Santa Lucía University Hospital) ;
Antúnez-López, José Ramon (University of Santiago de Compostela) ;
Kawazu, Masahito (Chiba Cancer Center, Research Institute, Chiba, Japan) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Andersen, Claus Lindbjerg (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Tubio, Jose M.C. (University of Santiago de Compostela) ;
López-López, Rafael (Centro de Investigación Biomédica en Red de Cáncer) ;
Ruiz-Bañobre, Juan (Centro de Investigación Biomédica en Red de Cáncer)
Deficiency in DNA MMR activity results in tumors with a hypermutator phenotype, termed microsatellite instability (MSI). Beyond its utility in Lynch syndrome screening algorithms, today MSI has gained importance as predictive biomarker for various anti-PD-1 therapies across many different tumor types. [...]
2023 -  10.1016/j.isci.2023.106127
iScience, Vol. 26 Núm. 3 (february 2023)
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2.
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28 p, 847.3 KB |
Explorando Patrones de Publicación en Revistas Académicas de Educación Lingüística : un Análisis Estadístico con Especial Atención a la Revista Bellaterra Journal
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Matos Palacios, Javier (Universidad de Extremadura) ;
Soto Vázquez, José (Universidad de Extremadura)
En el presente trabajo se lleva a cabo un análisis estadístico-comparativo de cuatro revistas: Bellaterra Journal, Porta Linguarum, ELIA y Tejuelo, con especial foco en Bellaterra, por ser una revista idiosincrática en el área, ya que solo publica textos de alumnos de grado y máster, de doctorandos y de postdoctorales de cinco años (con la excepción de un artículo invitado de un investigador sénior en cada número). [...]
En aquest treball es porta a terme una anàlisi estadístic-comparativa de quatre revistes: Bellaterra Journal, Porta Linguarum, ELIA i Tejuelo, amb especial focus a Bellaterra, per ser una revista idiosincràtica a l'àrea, ja que només publica textos de alumnes de grau i màster, de doctorands i de postdoctorals de cinc anys (excepte un article convidat d'un investigador sènior a cada número). [...]
This paper carries out a statistical-comparative analysis of four journals: Bellaterra Journal, Porta Linguarum, ELIA and Tejuelo, with a special focus on Bellaterra, as it is an idiosyncratic journal in the field, since it only publishes texts by undergraduate and master's degree students, doctoral students and five years postdoctoral students (with the exception of an invited article by a senior researcher in each issue). [...]
Cet article procède à une analyse statistique et comparative de quatre revues: Bellaterra Journal, Porta Linguarum, ELIA et Tejuelo, en mettant l'accent sur Bellaterra, car il s'agit d'une revue idiosyncrasique dans le domaine, puisqu'elle ne publie que des textes d'étudiants de licence et de master, de doctorants et de postdoctorants de cinq ans (à l'exception d'un article invité d'un chercheur chevronné dans chaque numéro). [...]
2023 - 10.5565/rev/jtl3.1325
Bellaterra journal of teaching and learning language and literature, Vol. 16 Núm. 4 (2023) , p. e1325 (Invited Authors)
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3.
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17 p, 477.5 KB |
Lifetime Dual Disorder Screening and Treatment Retention : A Pilot Cohort Study
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Puértolas-Gracia, Beatriz (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Barbaglia, María Gabriela (Institut d'Investigació Biomèdica Sant Pau) ;
Gotsens, Mercè (Institut d'Investigació Biomèdica Sant Pau) ;
Parés-Badell, Oleguer (Agència de Salut Pública de Barcelona) ;
Brugal, María Teresa (Agència de Salut Pública de Barcelona) ;
Torrens, Marta (Universitat de Vic - Universitat Central de Catalunya) ;
Treviño, Lara (Agència de Salut Pública de Barcelona) ;
Rodríguez-Díaz, Cconcepción (Agència de Salut Pública de Barcelona) ;
Vázquez-Vázquez, José María (Agència de Salut Pública de Barcelona) ;
Pascual, Alicia (Agència de Salut Pública de Barcelona) ;
Coromina-Gimferrer, Marcela (Agència de Salut Pública de Barcelona) ;
Jiménez-Dueñas, Míriam (Agència de Salut Pública de Barcelona) ;
Oliva, Israel (Agència de Salut Pública de Barcelona) ;
González, Erick (Agència de Salut Pública de Barcelona) ;
Mestre, Nicanor (Agència de Salut Pública de Barcelona) ;
Bartroli, Montserrat (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The coexistence of a substance use disorder and another mental disorder in the same individual has been called dual disorder or dual diagnosis. This study aimed to examine the prevalence of lifetime dual disorder in individuals with alcohol or cocaine use disorder and their retention in treatment. [...]
2022 - 10.3390/jcm11133760
Journal of clinical medicine, Vol. 11 Núm. 13 (7-1 2022) , p. 3760
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4.
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7 p, 586.0 KB |
Progress toward equitably managed protected areas in Aichi target 11 : a global survey
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Zafra-Calvo, Noelia (University of Copenhagen.) ;
Garmendía, Eneko (Universidad del País Vasco) ;
Pascual, Unai 1973- (Basque Centre for Climate Change (Bilbao)) ;
Palomo, Ignacio (Basque Centre for Climate Change (Bilbao)) ;
Gross-Camp, Nicole (University of East Anglia) ;
Brockington, Dan (The University of Sheffield) ;
Cortes Vazquez, Jose Antonio (Universidade da Coruña) ;
Coolsaet, Brendan (University of East Anglia) ;
Burgess, Neil David (University of Copenhagen)
The Convention on Biological Diversity Aichi Target 11 requires its 193 signatory parties to incorporate social equity into protected area (PA) management by 2020. However, there is limited evidence of progress toward this commitment. [...]
2019 - 10.1093/biosci/biy143
BioScience, Vol. 69 Núm. 3 (2019) , p. 191-197
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5.
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14 p, 1.9 MB |
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients : a randomised controlled trial
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Chastre, Jean (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
François, Bruno (Réanimation Polyvalente and Inserm CIC 1435 & UMR 1092. CHU) ;
Bourgeois, Marc (AZ Sint-Jan Brugge-Oostende AV) ;
Komnos, Apostolos (General Hospital of Larissa) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
Rahav, Galia (Chaim Sheba Medical Center. Sackler School of Medicine. Tel Aviv University) ;
De Schryver, Nicolas (Clinique Saint-Pierre) ;
Lepape, Alain (Hospices Civils de Lyon Hôpital Lyon Sud) ;
Koksal, Iftihar (Faculty of Medicine. Trabzon and Acibadem University Faculty of Medicine. Karadeniz Technical University) ;
Luyt, Charles-Edouard (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
Sánchez-García, Miguel (Hospital Clínico San Carlos. Unidad de Cuidados Intensivos) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona. Servei de Pneumologia) ;
Eggimann, Philippe (Department of Locomotor Apparatus. Centre Hospitalier Universitaire Vaudois CHUV) ;
Koulenti, Despoina (2nd Critical Care Department. Attikon University Hospital. National and Kapodistrian. University of Athens) ;
Holland, Thomas L. (Duke Clinical Research Institute) ;
Ali, Omar (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Shoemaker, Kathryn (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Ren, Pin (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Sauser, Julien (Infection Control Program. Faculty of Medicine. Geneva University Hospitals) ;
Ruzin, Alexey (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Tabor, David E. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Akhgar, Ahmad (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Wu, Yuling (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Jiang, Yu (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
DiGiandomenico, Antonio (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Colbert, Susan (Oncology. US SM&M. AstraZeneca) ;
Vandamme, Drieke (Inserm CIC 1435. CHU) ;
Coenjaerts, Frank (University Medical Center Utrecht) ;
Malhotra-Kumar, Surbhi (University of Antwerp. Laboratory of Medical Microbiology) ;
Timbermont, Leen (University of Antwerp. Laboratory of Medical Microbiology) ;
Oliver, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Barraud, Olivier (INSERM U1092. Centre Hospitalier Universitaire de Limoges. Université Limoges) ;
Bellamy, Terramika (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Bonten, Marc (Julius Center for Health Science and Primary Care. University Medical Center Utrecht. Utrecht University) ;
Goossens, Herman (Laboratory of Medical Microbiology. Vaccine and Infectious Disease Institute. University of Antwerp) ;
Reisner, Colin (DevPro Biopharma) ;
Esser, Mark T. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Jafri, Hasan S. (Late-Stage Development. Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Joannidis, Michael ;
Klimscha, Walter ;
De Waele, Elisabeth ;
Devriendt, Jacques ;
Huberlant, Vincent ;
Depuydt, Pieter ;
Van Boxstael, Sam ;
Peric, Mladen ;
Kopic, Jasminka ;
Hanauer, Michal ;
Hruby, Tomas ;
Sramek, Vladimir ;
Svoboda, Petr ;
Vymazal, Tomas ;
Novacek, Martin ;
Annane, Djillali ;
Mira, Jean-Paul ;
Souweine, Bertrand ;
Dequin, Pierre-François ;
Meziani, Ferhat ;
Stephan, François ;
Nseir, Saad ;
Gibot, Sebastien ;
Schwebel, Carole ;
Plantefeve, Gaetan ;
Diehl, Jean-Luc ;
Richard, Christian ;
Lamer, Christian ;
Klouche, Kada ;
Jaber, Samir ;
Zakynthinos, Epaminondas ;
Filntisis, Georgios ;
Zakynthinos, Spyros ;
Koutsoukou, Antonia ;
Saroglou, Georgios ;
Nikolaou, Charikleia ;
Vlachogianni, Glykeria ;
Pnevmatikos, Ioannis ;
Mandragos, Konstantinos ;
Kremer, Ildiko ;
Rozgonyi, Zsolt Dezso ;
Marjanek, Zsuzsa ;
Martin-Loeches, Ignacio ;
Singer, Pierre ;
Van Heerden, Vernon ;
Carmeli, Yehuda ;
Povoa, Pedro ;
AlvarezSeoane, Antonio ;
Moura, Pedro ;
Gonzalez, Filipe ;
Ramirez, Paula ;
Torres Marti, Antonio ;
Ferrer Roca, Ricard ;
Oteiza, Lorena ;
Escudero, Dolores ;
Piacentini, Enrique ;
Vera-Artazcoz, Paula (Institut d'Investigació Biomèdica Sant Pau) ;
Tamayo, Luis ;
Gonzalez Gallego, Miguel Angel ;
Suberviola Canas, Borja ;
Figueira, Iglesias ;
Leon, Rafael ;
Korten, Volkan ;
Akova, Murat ;
Wyncoll, Duncan ;
Whitehouse, Tony ;
Hopkins, Phil ;
Sim, Malcolm ;
Golan, Yoav ;
Zervos, Marcus ;
Vazquez, Jose ;
Cherabuddi, Kartikeya ;
Smulian, George ;
Rouphael, Nadine ;
Welker, James ;
Sims, Mathew ;
Van Duin, David ;
McCarthy, Todd ;
Polk, Christopher
Background: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. [...]
2022 - 10.1186/s13054-022-04204-9
Critical Care, Vol. 26 Núm. 1 (december 2022) , p. 355
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13 p, 1.2 MB |
Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA
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Ruiz Bañobre, Juan (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodríguez Casanova, Aitor (Universidade de Santiago de Compostela) ;
Costa-Fraga, Nicolás (Universidade de Santiago de Compostela) ;
Bao Caamano, Aida (Universidade de Santiago de Compostela) ;
Álvarez Castro, Ana (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Carreras Presas, Martín (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Brozos Vázquez, Elena (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Vidal Insua, Yolanda (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Vázquez Rivera, Francisca (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Candamio Folgar, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ;
Mosquera Presedo, Manuel (Universidade de Santiago de Compostela) ;
Lago Lestón, Ramón M. (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Muinelo-Romay, Laura (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Vázquez Bueno, José Ángel (Complejo Hospitalario Universitario de Ferrol) ;
Sanz Pamplona, Rebeca (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Moreno Aguado, Víctor (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Goel, Ajay (City of Hope Comprehensive Cancer Center) ;
Castillo, Lourdes (Advanced Marker Discovery) ;
Martín, Ana C. (Advanced Marker Discovery) ;
Arroyo, Rocío (Advanced Marker Discovery) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Crujeiras, Ana B. (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
López López, Rafael (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Diaz-Lagares, Angel (Complejo Hospitalario Universitario de Santiago de Compostela)
Background: Current noninvasive assays have limitations in the early detection of colorectal cancer. We evaluated the clinical utility of promoter methylation of the long noncoding RNA LINC00473 as a noninvasive biomarker to detect colorectal cancer and associated precancerous lesions. [...]
2022 - 10.1186/s13148-022-01302-x
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 86
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13 p, 2.0 MB |
Environmentalities of coexistence with wolves in the Cantabrian mountains of Spain
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Marino, Agnese (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Blanco, Juan Carlos (Consultores en Biologia de la Conservacion S.L.) ;
Cortes Vazquez, Jose Antonio (Universidad de A Coruña. Departamento de Sociología y Comunicación) ;
Lopez-Bao, José Vicente (Universidad de Oviedo. Instituto de Investigación de la Biodiversidad - CSIC) ;
Planella Bosch, Anna (Universidad de Oviedo. Unidad de Investigación de la Biodiversidad) ;
Durant, Sarah (Zoological Society of London. Institute of Zoology)
Coexistence between humans and large carnivores is mediated by diverse values and interactions. We focus on four sites in the Cantabrian Mountains of Spain with a history of continuous wolf presence to examine how perceptions of coexistence vary across contexts. [...]
2022 - 10.4103/cs.cs_66_21
Conservation and Society, Vol. 20, Issue 4 (2022) , p. 345-357
2 documents
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8 p, 803.0 KB |
The effectiveness of a web-based decision aid for patients with hip osteoarthritis : Study protocol for a randomized controlled trial
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Perestelo-Pérez, Lilisbeth (Center for Biomedical Research of the Canary Islands) ;
Álvarez-Pérez, Yolanda (Fundación Canaria Instituto de Investigación Sanitaria de Canarias) ;
Rivero-Santana, Amado (Fundación Canaria Instituto de Investigación Sanitaria de Canarias) ;
Ramos-García, Vanesa (Fundación Canaria Instituto de Investigación Sanitaria de Canarias) ;
Duarte-Díaz, Andrea (Fundación Canaria Instituto de Investigación Sanitaria de Canarias) ;
Torres-Castaño, Alezandra (Fundación Canaria Instituto de Investigación Sanitaria de Canarias) ;
Toledo-Chávarri, Ana (Fundación Canaria Instituto de Investigación Sanitaria de Canarias) ;
Herrera-Perez, Mario (Hospital Universitario de Canarias (La Laguna)) ;
País-Brito, José Luis (Hospital Universitario de Canarias (La Laguna)) ;
Del Castillo, José Carlos (Hospital San Juan de Dios de Santa Cruz de Tenerife) ;
Vázquez, José Ramon (Gerencia de Atención Primaria de Tenerife Del Servicio Canario de la Salud) ;
Orrego, Carola (Universitat Autònoma de Barcelona. Institut Universitari Avedis Donabedian) ;
Serrano-Aguilar, Pedro (Center for Biomedical Research of the Canary Islands)
Background: Osteoarthritis (OA) is a health condition sensitive to patient's preferences and values regarding the benefits and risks of the different treatment options. In this sense, patient decision aids (PtDA) can play an important role in helping patients to incorporate their values, needs, and preferences into the decision-making process, thus improving person-centered care. [...]
2020 - 10.1186/s13063-020-04661-z
Trials, Vol. 21 Núm. 1 (24 2020) , p. 736
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13 p, 3.2 MB |
In Silico Assessment of the Lipid Fingerprint Signature of ATP2, the Essential P4-ATPase of Malaria Parasites
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López-Martín, Mario (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Renault, Pedro (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Vázquez-Ibar, José Luis (Université Paris-Saclay) ;
Perálvarez-Marín, Álex (Universitat Autònoma de Barcelona. Institut de Neurociències)
ATP2, a putative type 4 P-type ATPase, is a phosphatidylinositol-4-phosphate (PI4P)-regulated phospholipid transporter with an interesting potential as an antimalarial drug target due to its conservation across Plasmodium species and its essential role in the life cycle of Plasmodium falciparum. [...]
2022 - 10.3390/membranes12070702
Membranes, Vol. 12 Núm. 7 (july 2022) , p. 702
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16 p, 264.5 KB |
El aprendizaje autodirigido en el marco de las ecologías de formación inicial docente : resultados de un estudio Delphi
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Santos Caamaño, Francisco José (Universidade da Coruña) ;
Vázquez Cancelo, María José (Universidade da Coruña) ;
Fuentes Abeledo, Eduardo José (Universidade de Santiago de Compostela)
El uso de las TIC y, particularmente, las tecnologías de redes han ampliado las posibilidades de acceder a nuevos espacios y recursos para el aprendizaje, más allá del tradicional campo formal escolar. [...]
L'ús de les TIC i, particularment, les tecnologies de xarxes han ampliat les possibilitats d'accedir a nous espais i recursos per aprendre, més enllà del tradicional camp formal escolar. Tot i així, aquestes combinacions d'ambients múltiples i diferents hi afegeixen un element de complexitat que exigeix més esforç a l'estudiant en el paper de director del seu propi aprenentatge. [...]
The use of ICT, and particularly network technologies, has expanded the possibilities of access to new learning spaces and resources beyond traditional formal school settings. However, these combinations of multiple and different environments add an element of complexity, which requires learners to make a greater effort in their role as directors of their own learning. [...]
2022 - 10.5565/rev/educar.1526
Educar, Vol. 58 Núm. 2 (2022) , p. 357-372 (Monográfico)
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