Microrheometer for Biofluidic Analysis : Electronic Detection of the Fluid-Front Advancement
Méndez-Mora, Lourdes (Universitat de Barcelona)
Cabello-Fusarés, Maria (Centre de Recerca Matemàtica)
Ferré-Torres, Josep (Universitat de Barcelona)
Riera-Llobet, Carla (Universitat de Barcelona)
López, Samantha (Universitat de Barcelona)
Trejo-Soto, Claudia (Pontificia Universidad Católica de Valparaíso)
Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
Hernández-Machado, Aurora (Universitat de Barcelona)

Data:	2021
Resum:	The motivation for this study was to develop a microdevice for the precise rheological characterization of biofluids, especially blood. The method presented was based on the principles of rheometry and fluid mechanics at the microscale. Traditional rheometers require a considerable amount of space, are expensive, and require a large volume of sample. A mathematical model was developed that, combined with a proper experimental model, allowed us to characterize the viscosity of Newtonian and non-Newtonian fluids at different shear rates. The technology presented here is the basis of a point-of-care device capable of describing the nonlinear rheology of biofluids by the fluid/air interface front velocity characterization through a microchannel. The proposed microrheometer uses a small amount of sample to deliver fast and accurate results, without needing a large laboratory space. Blood samples from healthy donors at distinct hematocrit percentages were the non-Newtonian fluid selected for the study. Water and plasma were employed as testing Newtonian fluids for validation of the system. The viscosity results obtained for the Newtonian and non-Newtonian fluids were consistent with pertinent studies cited in this paper. In addition, the results achieved using the proposed method allowed distinguishing between blood samples with different characteristics.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1061 Ministerio de Economía y Competitividad MTM2015-71509-C2-1-R Ministerio de Economía y Competitividad MDM-2014-0445 Ministerio de Economía y Competitividad FIS2016-78883-C2-1P Agencia Estatal de Investigación PID2019-106063GB-I00
Nota:	Altres ajuts: Generalitat de Catalunya: 2018/DI-068, 2018/DI-064
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Rheometer ; Microrheometer ; Rheology ; Hemorheology ; Viscosity ; Blood ; Plasma
Publicat a:	Micromachines, Vol. 12, Num. 6 (June 2021) , art. 726, ISSN 2072-666X

DOI: 10.3390/mi12060726
PMID: 34203063

20 p, 3.7 MB

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