Characteristics and outcomes of 627 044 COVID-19 patients living with and without obesity in the United States, Spain, and the United Kingdom
Recalde, Martina (Universitat Autònoma de Barcelona)
Roel, Elena (Universitat Autònoma de Barcelona)
Pistillo, Andrea (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Sena, Anthony G. (Erasmus University Medical Center. Department of Medical Informatics)
Prats-Uribe, Albert (University of Oxford. Centre for Statistics in Medicine)
Ahmed, Waheed-Ul-Rahman (University of Exeter. College of Medicine and Health)
Alghoul, Heba (Islamic University of Gaza. Faculty of Medicine)
Alshammari, Thamir (Riyadh Elm University. College of Pharmacy)
Alser, Osaid (Harvard Medical School)
Areia, Carlos (University of Oxford. Nuffield Department of Clinical Neurosciences)
Burn, Edward (University of Oxford. Centre for Statistics in Medicine)
Casajust, Paula (Trial Form Support (Barcelona, Catalunya))
Dawoud, Dalia (Cairo University. Faculty of Pharmacy)
DuVall, Scott L. (University of Utah School of Medicine. Department of Internal Medicine)
Falconer, Thomas (Columbia University. Department of Biomedical Informatics)
Fernández-Bertolín, Sergio (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Golozar, Asieh (Regeneron Pharmaceuticals. Pharmacoepidemiology)
Gong, Mengchun (DHC Technologies)
Lai, Lana Yin Hui (University of Manchester. Division of Cancer Sciences)
Lane, Jennifer C. E. (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences)
Lynch, Kristine E. (University of Utah School of Medicine. Department of Internal Medicine)
Matheny, Michael E. (Vanderbilt University Medical Center. Department of Biomedical Informatics)
Mehta, Paras P. (The University of Arizona. College of Medicine)
Morales, Daniel R. (University of Dundee. Division of Population Health and Genomics)
Natarjan, Karthik (New York-Presbyterian Hospital)
Nyberg, Fredrik (University of Gothenburg. Institute of Medicine)
Posada, Jose D. (Stanford University. Department of Medicine)
Reich, Christian G. (Real World Solutions)
Rijnbeek, Peter R. (Erasmus University Medical Center. Department of Medical Informatics)
Schilling, Lisa M. (University of Colorado Anschutz Medical Campus. Department of Medicine)
Shah, Karishma (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences)
Shah, Nigam H. (Stanford University. Department of Medicine)
Subbian, Vignesh (The University of Arizona. College of Engineering)
Zhang, Lin (The University of Melbourne. Melbourne School of Population and Global Health)
Zhu, Hong (Southern Medical University. Nanfang Hospital)
Ryan, Patrick (Columbia University. Department of Biomedical Informatics)
Prieto-Alhambra, Daniel (University of Oxford. Centre for Statistics in Medicine)
Kostka, Kristin (Northeastern University. The OHDSI Center at the Roux Institute)
Duarte-Salles, Talita 1985- (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)

Data:	2021
Resum:	A detailed characterization of patients with COVID-19 living with obesity has not yet been undertaken. We aimed to describe and compare the demographics, medical conditions, and outcomes of COVID-19 patients living with obesity (PLWO) to those of patients living without obesity. We conducted a cohort study based on outpatient/inpatient care and claims data from January to June 2020 from Spain, the UK, and the US. We used six databases standardized to the OMOP common data model. We defined two non-mutually exclusive cohorts of patients diagnosed and/or hospitalized with COVID-19; patients were followed from index date to 30 days or death. We report the frequency of demographics, prior medical conditions, and 30-days outcomes (hospitalization, events, and death) by obesity status. We included 627 044 (Spain: 122 058, UK: 2336, and US: 502 650) diagnosed and 160 013 (Spain: 18 197, US: 141 816) hospitalized patients with COVID-19. The prevalence of obesity was higher among patients hospitalized (39. 9%, 95%CI: 39. 8−40. 0) than among those diagnosed with COVID-19 (33. 1%; 95%CI: 33. 0−33. 2). In both cohorts, PLWO were more often female. Hospitalized PLWO were younger than patients without obesity. Overall, COVID-19 PLWO were more likely to have prior medical conditions, present with cardiovascular and respiratory events during hospitalization, or require intensive services compared to COVID-19 patients without obesity. We show that PLWO differ from patients without obesity in a wide range of medical conditions and present with more severe forms of COVID-19, with higher hospitalization rates and intensive services requirements. These findings can help guiding preventive strategies of COVID-19 infection and complications and generating hypotheses for causal inference studies.
Ajuts:	European Commission. Horizon 2020 806968
Nota:	Altres ajuts: This research received partial support from the National Institute for Health Research (NIHR) Oxford Biomedical Research Center (BRC), US National Institutes of Health, US Department of Veterans Affairs, Janssen Research & Development, and IQVIA. The University of Oxford received funding related to this work from the Bill & Melinda Gates Foundation (Investment ID INV016201 and INV-019257). APU has received funding from the Medical Research Council (MRC) [MR/K501256/1, MR/N013468/1] and Fundación Alfonso Martín Escudero (FAME) (APU). VINCI [VA HSR RES 13-457] (SLD, MEM, KEL). JCEL has received funding from the Medical Research Council (MR/K501256/1) and Versus Arthritis (21605). MR is funded by Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant program [grant number: 2017/1630]
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Estudi clínic ; recerca ; Versió publicada
Matèria:	Epidemiology ; Public health
Publicat a:	International Journal of Obesity, Vol. 45 (july 2021) , p. 2347-2357, ISSN 1476-5497

DOI: 10.1038/s41366-021-00893-4
PMID: 34267326

11 p, 2.3 MB

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