Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients
Chauvin, Manon (Sorbonne Université)
Larsen, Martin (Sorbonne Université)
Quirant, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Quentric, Paul (Sorbonne Université)
Dorgham, Karim (Sorbonne Université)
Royer, Luca (Sorbonne Université)
Vallet, Hélène (Assistance Publique-Hôpitaux de Paris)
Guihot, Amelie (Assistance Publique-Hôpitaux de Paris)
Combadiere, Behazine (Sorbonne Université)
Combadière, Christophe (Sorbonne Université)
Barallat, Jaume (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mayaux, Julien (Assistance Publique-Hôpitaux de Paris)
Luyt, Charles-Edouard (Assistance Publique-Hôpitaux de Paris)
Mathian, Alexis (Assistance Publique Hôpitaux de Paris)
Amoura, Zahir (SAssistance Publique Hôpitaux de Paris)
Boddaert, Jacques (Assistance Publique-Hôpitaux de Paris)
Arméstar, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)
Gorochov, Guy (Assistance Publique-Hôpitaux de Paris (AP-HP))
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sauce, Delphine (Sorbonne Université)

Date:	2021
Abstract:	Innate immune activation during Covid-19 infection is associated with pernicious clinical outcome. Coronavirus disease 2019 (Covid-19) is a worldwide threat that has already caused more than 3 000 000 deaths. It is characterized by different patterns of disease evolution depending on host factors among which old-age and pre-existing comorbidities play a detrimental role. Previous coronavirus epidemics, notably SARS-CoV, were associated with increased serum neopterin levels, which can be interpreted as a sign of acute innate immunity in response to viral infection. Here we hypothesize that neopterin may serve as a biomarker of SARS-CoV-2 viral infection and Covid-19 disease severity. We measured neopterin blood levels by ELISA. Seric concentration was quantified from 256 healthy donors and 374 Covid-19 patients at hospital admission. Enrolled Covid-19 patients were all symptomatic and displayed a large spectrum of comorbidities. Patients were followed until disease resolution or death. Severe and critically ill SARS-CoV-2 infected patients were characterized by a profound exacerbation of immune activation characterized by elevated neopterin blood levels. Systemic neopterin levels above 19nM stratified healthy individuals from Covid-19 patients with 87% specificity and 100% sensitivity. Moreover, systemic neopterin levels above 53nM differentiated non-survivors from survivors with 64% specificity and 100% sensitivity. We propose that neopterin concentration measured at arrival to hospital is a hallmark of severe Covid-19 and identifies a high-risk population of pernicious clinical outcome with a need for special medical care.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	SARS-CoV-2 ; Biomarker ; Neopterin ; Clinical outcome ; Death
Published in:	Frontiers in cellular and infection microbiology, Vol. 11 (August 2021) , art. 709893, ISSN 2235-2988

DOI: 10.3389/fcimb.2021.709893
PMID: 34497777

9 p, 2.6 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles