Graphene, other carbon nanomaterials and the immune system : toward nanoimmunity-by-design
Gazzi, Arianna (Basque Foundation for Science)
Fusco, Laura (Basque Foundation for Science)
Orecchioni, Marco (University of Sassari. Department of Chemistry and Pharmacy)
Ferrari, Silvia (University of Sassari. Department of Chemistry and Pharmacy)
Franzoni, Giulia (Istituto Zooprofilattico Sperimentale della Sardegna)
Yan, J. Stephen (Rice University. Smalley-Curl Institute. Department of Chemical and Biomolecular Engineering. Department of Chemistry)
Rieckher, Matthias (University of Cologne. Institute for Genome Stability in Aging and Disease. Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD). Center for Molecular Medicine Cologne (CMMC))
Peng, Guotao (Karolinska Institutet (Estocolm, Suècia). Institute of Environmental Medicine)
Lucherelli, Matteo Andrea (Centre National de la Recherche Scientifique (França))
Vacchi, Isabella Anna (Centre National de la Recherche Scientifique (França))
Quyen Chau, Ngoc Do (Centre National de la Recherche Scientifique (França))
Criado, Alejandro (CIC BiomaGUNE. Carbon Nanobiotechnology Laboratory)
Istif, Akcan (University of Trieste. Department of Chemical and Pharmaceutical Sciences)
Mancino, Donato (CIC BiomaGUNE. Carbon Nanobiotechnology Laboratory)
Dominguez, Antonio (CIC BiomaGUNE. Carbon Nanobiotechnology Laboratory)
Eckert, Hagen (Institute for Materials Science and Max Bergmann Center of Biomaterials)
Vázquez, Ester (Universidad de Castilla-La Mancha. Instituto Regional de Investigacion Cientifica Aplicada)
Da Ros, Tatiana (University of Trieste. Department of Chemical and Pharmaceutical Sciences)
Nicolussi, Paola (Istituto Zooprofilattico Sperimentale della Sardegna)
Palermo, Vincenzo (Chalmers University of Technology, Industrial and Materials Science)
Schumacher, Björn (University of Cologne. Institute for Genome Stability in Aging and Disease. Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD). Center for Molecular Medicine Cologne (CMMC))
Cuniberti, Gianaurelio (Institute for Materials Science and Max Bergmann Center of Biomaterials)
Mai, Yiyong (Shanghai Jiao Tong University. School of Chemistry and Chemical Engineering)
Clementi, Cecilia (Rice University. Smalley-Curl Institute. Department of Chemical and Biomolecular Engineering. Department of Chemistry)
Pasquali, Matteo (Rice University. Smalley-Curl Institute. Department of Chemical and Biomolecular Engineering. Department of Chemistry)
Feng, Xinliang (Technische Universität Dresden. Center for Advancing Electronics)
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Yilmazer, Acelya (University of Ankara. Stem Cell Institute)
Bedognetti, Davide (Sidra Medicine (Qatar). Cancer Research Department)
Fadeel, Bengt (Karolinska Institutet (Estocolm, Suècia). Institute of Environmental Medicine)
Prato, Maurizio (Basque Foundation for Science)
Bianco, Alberto (Centre National de la Recherche Scientifique (França))
Delogu, Lucia Gemma (University of Padua. Department of Biomedical Sciences)

Date:	2020
Abstract:	Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and carbon dots, have attracted a great deal scientific attention due to their potential as biomedical tools. Following exposure, particularly intravenous injection, these nanomaterials can be recognized by immune cells. Such interactions could be modulated by the different physicochemical properties of the materials (e. g. structure, size, and chemical functions), by either stimulating or suppressing the immune response. However, a harmonized cutting-edge approach for the classification of these materials based not only on their physicochemical parameters but also their immune properties has been missing. The European Commission-funded G-IMMUNOMICS and CARBO-IMmap projects aimed to fill this gap, developing a functional pipeline for the qualitative and quantitative immune characterization of graphene, graphene-related materials (GRMs), and other CBMs. The goal was to open breakthrough perspectives for the definition of the immune profiles of these materials. Here, we summarize our methodological approach, key results, and the necessary multidisciplinary expertise ranging across various fields, from material chemistry to engineering, immunology, toxicology, and systems biology. G-IMMUNOMICS, as a partnering project of the Graphene Flagship, the largest scientific research initiative on graphene worldwide, also complemented the studies performed in the Flagship on health and environmental impact of GRMs. Finally, we present the nanoimmunity-by-design concept, developed within the projects, which can be readily applied to other 2D materials. Overall, the G-IMMUNOMICS and CARBO-IMmap projects have provided new insights on the immune impact of GRMs and CBMs, thus laying the foundation for their safe use and future translation in medicine.
Grants:	European Commission 734381 Agencia Estatal de Investigación MDM-2017-0720
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Graphene ; Carbon nanotubes ; Nanomedicine ; Nanosafety ; Nanotoxicology ; Single cell mass cytometry ; Systems biology
Published in:	JPhys materials, Vol. 3, Issue 3 (July 2020) , art. 34009, ISSN 2515-7639

DOI: 10.1088/2515-7639/ab9317

20 p, 4.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles