Sow vaccination with a protein fragment against virulent glaesserella (Haemophilus) parasuis modulates immunity traits in their offspring
López-Serrano, Sergi 
(Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Neila-Ibáñez, Carlos María 
(Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Costa-Hurtado, Mar (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Mahmmod, Yasser 
(Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Martínez-Martínez, Jorge (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Galindo Cardiel, Iván (Parque Magnus-Polígono Empresarium. WorldPathol)
Darji, Ayub
(Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Rodriguez, Fernando
(Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Sibila, Marina
(Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Aragon, Virginia
(Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Data: |
2021 |
Resum: |
Glaesserella (Haemophilus) parasuis, an early colonizer of the nasal cavity in piglets, is a highly heterogeneous species, comprising both commensal and virulent strains. Virulent G. parasuis strains can cause fibrinous polyserositis called Glässer's disease. Colostrum is a source of passive immunity for young piglets. When vaccinating sows, protective antibodies are transferred to their offspring through the colostrum. Here, sow vaccination was performed with a protein fragment, F4, from the outer membrane trimeric autotransporters VtaAs exclusively found in virulent G. parasuis. Piglets were allowed to suckle for 3 weeks, following which a challenge with two virulent strains of G. parasuis was performed. A group of nonvaccinated sows and their piglets were included as a control. Antibodies against F4 were confirmed using ELISA in the vaccinated sows and their offspring before the G. parasuis challenge. Compared to the control group, F4-vaccination also resulted in an increased level of serum TGF-β both in vaccinated sows and in their offspring at early time points of life. After the challenge, a lower body temperature and a higher weight were observed in the group of piglets from vaccinated sows. One piglet from the non-vaccinated group succumbed to the infection, but no other significant differences in clinical signs were noticed. At necropsy, performed 2 weeks after the virulent challenge, the level of surfactant protein D (SP-D) in bronchoalveolar lavage was higher in the piglets from vaccinated sows. Vaccination did not inhibit the nasal colonization of the piglets by the challenge strains. |
Ajuts: |
Ministerio de Economía y Competitividad AGL2016-77361-R
|
Drets: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
Swine ;
Bacteria ;
Disease ;
Vaccine ;
Glaesserella parasuis |
Publicat a: |
Vaccines (Basel), Vol. 9 Núm. 5 (may 2021) , p. 534, ISSN 2076-393X |
DOI: 10.3390/vaccines9050534
PMID: 34065547
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Registre creat el 2022-01-11, darrera modificació el 2023-11-10