Inappropriate sinus tachycardia in post-COVID-19 syndrome
Aranyó, Júlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bazán, Víctor (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Lladós, Gemma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Dominguez, Maria Jesús (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bisbal, Felipe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Sarrias, Axel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Adeliño, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Riverola, Ariadna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona)
Mateu, Lourdes (Universitat Autònoma de Barcelona)
Villuendas-Sabaté, Roger (Universitat Autònoma de Barcelona)

Fecha:	2022
Resumen:	Inappropriate sinus tachycardia (IST) is a common observation in patients with post-COVID-19 syndrome (PCS) but has not yet been fully described to date. To investigate the prevalence and the mechanisms underlying IST in a prospective population of PCS patients. Consecutive patients admitted to the PCS Unit between June and December 2020 with a resting sinus rhythm rate ≥ 100 bpm were prospectively enrolled in this study and further examined by an orthostatic test, 2D echocardiography, 24-h ECG monitoring (heart rate variability was a surrogate for cardiac autonomic activity), quality-of-life and exercise capacity testing, and blood sampling. To assess cardiac autonomic function, a 2:1:1 comparative sub-analysis was conducted against both fully recovered patients with previous SARS-CoV-2 infection and individuals without prior SARS-CoV-2 infection. Among 200 PCS patients, 40 (20%) fulfilled the diagnostic criteria for IST (average age of 40. 1 ± 10 years, 85% women, 83% mild COVID-19). No underlying structural heart disease, pro-inflammatory state, myocyte injury, or hypoxia were identified. IST was accompanied by a decrease in most heart rate variability parameters, especially those related to cardiovagal tone: pNN50 (cases 3. 2 ± 3 vs. recovered 10. 5 ± 8 vs. non-infected 17. 3 ± 10; p < 0. 001) and HF band (246 ± 179 vs. 463 ± 295 vs. 1048 ± 570, respectively; p < 0. 001). IST is prevalent condition among PCS patients. Cardiac autonomic nervous system imbalance with decreased parasympathetic activity may explain this phenomenon.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cardiology ; Cardiovascular biology ; Cardiovascular diseases
Publicado en:	Scientific reports, Vol. 12 (january 2022) , ISSN 2045-2322

DOI: 10.1038/s41598-021-03831-6
PMID: 34996973

9 p, 1.4 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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