One- and 2-year incidence of osteoporotic fracture : a multi-cohort observational study using routinely collected real-world data
Khalid, Sara (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences)
Reyes, Carlen (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Ernst, Martin (University of Southern Denmark. Department of Public Health, Clinical Pharmacology and Pharmacy)
Delmestri, Antonella (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences)
Toth, Emese (UCB Biopharma Sprl)
Libanati, Cesar (UCB Biopharma Sprl)
Abrahamsen, Bo (Holbæk Hospital (Dinamarca))
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona)

Data:	2021
Resum:	We estimated and characterized the imminent fracture risk (1-2 years) of high-risk fracture patients through a multinational (UK, Spain, Denmark) cohort study. Older individuals with newly diagnosed osteoporosis and individuals who had a fracture while on treatment with a bisphosphonate were at a high risk of imminent fracture. To characterize and estimate 1- to 2-year fracture risk in high-risk fracture patients. Multi-cohort study in (database/study period) UK (CPRD/1995-2017), Spain (SIDIAP/2006-2016) and Denmark (DHR/1995-2016) including individuals ≥ 50 years old in NDO (newly diagnosed osteoporosis), OFx (incident osteoporotic fracture), BP (incident oral bisphosphonates use) or FWOT (fracture while on treatment with bisphosphonates). Outcomes (ICD-10/READ): hip, clinical spine, non-hip, non-spine and hip/humerus/distal forearm fracture. Follow-up: from cohort entry until death, migration/transfer or end of the study. Statistics: baseline characteristics and incidence rate (IR per 1000 persons). NDO included 69,899 (UK), 37,901 (Spain) and 158,191 (Denmark) individuals. Spanish-IR was lowest for hip (4. 7), clinical spine (2. 5) and major osteoporotic fracture (MOF) (17. 3) and highest in Denmark (74. 2, 26. 0 and 120. 1, respectively). OFx included 83,514 (UK), 51,044 (Spain) and 509,551 (Denmark) individuals. IR in Denmark was highest for hip (24. 1) and MOF (47. 2), in Spain was highest for the clinical spine (9. 4) and lowest for hip (9. 5) and in the UK was lowest for the clinical spine (2. 8) and MOF (20. 7). BP included 148,507 (UK), 52,037 (Spain) and 204,010 (Denmark) individuals. Spanish-IR was lowest for hip (5. 0) and MOF (21. 1) and highest in Denmark (20. 3 and 48. 6, respectively). FWOT included 28,930 (UK), 1,865 (Spain) and 31,882 (Denmark) individuals. Clinical spine-IR was highest for Spain (12. 0). Hip-IR was lowest for Spain (7. 6) and highest for Denmark (33. 6). Comparing young subjects, those who have FWOT started with an increased fracture rate. OFx and FWOT individuals experience higher re-fracture incidence rates than those with osteoporosis with or without treatment. The online version contains supplementary material available at 10. 1007/s00198-021-06077-0.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Osteoporosis ; General population studies ; Anti-resorptive ; Fracture prevention
Publicat a:	Osteoporosis International, Vol. 33 (2022) , p. 123-137, ISSN 1433-2965

DOI: 10.1007/s00198-021-06077-0
PMID: 34392386

15 p, 1.4 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats