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| Pàgina inicial > Articles > Articles publicats > Focusing on Comorbidity-A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders |
(Universitat de Barcelona. Departament de Medicina) (Hospital Clínic i Provincial de Barcelona) (Hospital Clinic. Schizophrenia Unit) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Institut Català d'Oncologia) (Clinical Academic Center (Braga)) (King's College London. Department of Psychosis Studies) (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) (King's College London. Department of Child and Adolescent Psychiatry) (Stockholm County Council. Stockholm Health Care Services) (Institut de Recerca Sant Joan de Déu) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) (Ottawa Hospital Research Institute. Clinical Epidemiology Program) (Hospital Clinic. Psychiatric and Psychology Service) (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience)
| Data: | 2022 |
| Resum: | In mental health, comorbidities are the norm rather than the exception. However, current meta-analytic methods for summarizing the neural correlates of mental disorders do not consider comorbidities, reducing them to a source of noise and bias rather than benefitting from their valuable information. We describe and validate a novel neuroimaging meta-analytic approach that focuses on comorbidities. In addition, we present the protocol for a meta-analysis of all major mental disorders and their comorbidities. The novel approach consists of a modification of Seed-based d Mapping-with Permutation of Subject Images (SDM-PSI) in which the linear models have no intercept. As in previous SDM meta-analyses, the dependent variable is the brain anatomical difference between patients and controls in a voxel. However, there is no primary disorder, and the independent variables are the percentages of patients with each disorder and each pair of potentially comorbid disorders. We use simulations to validate and provide an example of this novel approach, which correctly disentangled the abnormalities associated with each disorder and comorbidity. We then describe a protocol for conducting the new meta-analysis of all major mental disorders and their comorbidities. Specifically, we will include all voxel-based morphometry (VBM) studies of mental disorders for which a meta-analysis has already been published, including at least 10 studies. We will use the novel approach to analyze all included studies in two separate single linear models, one for children/adolescents and one for adults. The novel approach is a valid method to focus on comorbidities. The meta-analysis will yield a comprehensive atlas of the neuroanatomy of all major mental disorders and their comorbidities, which we hope might help develop potential diagnostic and therapeutic tools. |
| Ajuts: | Instituto de Salud Carlos III CPII19/0009 Instituto de Salud Carlos III FI20/00047 Instituto de Salud Carlos III PI19/00394 European Commission. Horizon 2020 PI19/00394 "la Caixa" Foundation PI19/00394 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Meta-analysis ; Magnetic resonance imaging (MRI) ; Seed-based d mapping (SDM) ; Gray matter (GM) ; Mental disorder ; Comorbidity ; Medication |
| Publicat a: | Frontiers in psychiatry, Vol. 12 (january 2022) , ISSN 1664-0640 |
