Assessment of the biological potential of diaryltriazene-derived triazene compounds
Figueirêdo, Patricia de Maria Silva (Federal University of Maranhão. Laboratório de Microbiologia Clínica)
Sampaio Filho, José Costa (University of Ceuma. Electrochemistry and Biotechnology Laboratory)
Sodré, Alzirene de Jesus Sales (Federal University of Maranhão. Laboratório de Microbiologia Clínica)
de Castro Júnior, José Ribamar (Federal University of Maranhão. Laboratório de Microbiologia Clínica)
Gonçalves, Ingrid Santos (University of Ceuma. Electrochemistry and Biotechnology Laboratory)
Blasques, Rodrigo Vieira (Federal University of São Carlos. Department of Nature Sciences, Mathematics, and Education)
S. Correa, Rodrigo (Federal University of Ouro Preto. Instituto de Ciências Exatas e Biológicas)
Lima, Benedicto Augusto Vieira (Federal University of Maranhão)
dos Anjos Marques, Larissa (Federal University of Maranhão. Laboratório de Microbiologia Clínica)
Coutinho, Denise Fernandes (Federal University of Maranhão. Laboratório de Farmacognosia)
de Azevedo dos Santos, Ana Paula Silva (Federal University of Maranhão. Laboratório de Imunologia Aplicada ao Câncer)
Luz, Tássio Rômulo Silva Araújo (Federal University of Maranhão. Laboratório de Farmacognosia)
de Miranda, Rita de Cassia Mendonça (University of Ceuma. Electrochemistry and Biotechnology Laboratory)
dos Santos, Julliana Ribeiro Alves (University of Ceuma. Laboratory of Environmental Microbiology)
Doriguetto, Antonio Carlos (Federal University of Alfenas. Institute of Chemistry)
Pividori, María Isabel (Universitat Autònoma de Barcelona. Departament de Química)
Hörner, Manfredo (Federal University of Santa Maria. Department of Chemistry)
Villis, Paulo Cesar Mendes (University of Ceuma. Electrochemistry and Biotechnology Laboratory)

Data:	2021
Resum:	In the present study, novel, 1,3-diaryltriazene-derived triazene compounds were synthesized and tested. Triazenes are versatile and belong to a group of alkylating agents with interesting physicochemical properties and proven biological activities. This study describes the synthesis, molecular and crystalline structure, biological activity evaluation, and antifungal and antimicrobial potentials of 1,3- bis (X-methoxy-Y-nitrophenyl)triazenes [X = 2 and 5; Y = 4 and 5]. The antimicrobial and antifungal activities of the compounds were tested by evaluating the sensitivity of bacteria (American Type Culture Collection, ATCC) and clinical isolates to their solutions using standardized microbiological assays, cytotoxicity evaluation, and ecotoxicity tests. The antimicrobial potentials of triazenes were determined according to their minimum inhibitory concentrations (MICs); these compounds were active against gram-positive and gram-negative bacteria, with low MIC values. The most surprising result was obtained for T3 having the effective MIC of 9. 937 µg/mL and antifungal activity against Candida albicans ATCC 90028, C. parapsilosis ATCC 22019, and C. tropicallis IC. To the best of our knowledge, this study is the first to report promising activities of triazene compounds against yeast and filamentous fungi. The results showed the potential utility of triazenes as agents affecting selected resistant bacterial and fungal strains.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Microbiology ; Chemistry ; Drug discovery
Publicat a:	Scientific reports, Vol. 11 (January 2021) , art. 2541, ISSN 2045-2322

DOI: 10.1038/s41598-021-81823-2
PMID: 33510223

15 p, 2.1 MB

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