Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
Gómez-Segura, Lídia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Parra Coca, Alexander (University of Applied and Environmental Sciences. Department of Veterinary Medicine and Zootechnic)
Calpena-Campmany, Ana Cristina (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia)
Gimeno, Álvaro (Institut d'Investigació Biomèdica de Bellvitge)
Gómez de Aranda, Immaculada (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental)
Boix-Montañes, Antonio (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia)

Data:	2020
Resum:	(1) Background: Carprofen (CP), 2-(6-chlorocarbazole) propionic acid, is used as an anti-inflammatory, analgesic and anti-pyretic agent and it belongs to the family of non-steroidal anti-inflammatory drugs (NSAIDs). CP has some adverse reactions in systemic administration; for this reason, topical administration with CP nanoparticles (CP-NPs) can be an optimal alternative. The main objective of this work is the investigation of ex vivo permeation of CP through different types of porcine mucous membranes (buccal, sublingual and vaginal) and ophthalmic tissues (cornea, sclera and conjunctiva) to compare the influence of CP-NPs formulation over a CP solution (CP-Solution). (2) Methods: The ex vivo permeation profiles were evaluated using Franz diffusion cells. Furthermore, in vivo studies were performed to verify that the formulations did not affect the cell structure and to establish the amount retained (Qr) in the tissues. (3) Results: Permeation of CP-NPs is more effective in terms of drug retention in almost all tissues (with the exception of sclera and sublingual). In vivo studies show that neither of the two formulations affects tissue structure, so both formulations are safe. (4) Conclusions: It was concluded that CP-NPs may be a useful tool for the topical treatment of local inflammation in veterinary and human medicine.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Nanoparticles ; Carprofen ; Solution ; Drug delivery system ; Anti-inflammatory ; Veterinary diseases ; NSAIDs
Publicat a:	Nanomaterials, Vol. 10 (february 2020) , ISSN 2079-4991

DOI: 10.3390/nano10020355
PMID: 32085577

16 p, 5.8 MB

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