Genomic analysis of European Drosophila melanogaster populations reveals longitudinal structure, continent-wide selection, and previously unknown DNA viruses
Kapun, Martin (The European Drosophila Population Genomics Consortium)
Barrón Aduriz, Maite Garazi (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Staubach, Fabian (University of Freiburg. Department of Evolutionary Biology and Ecology)
Obbard, Darren J. (University of Edinburgh. Institute of Evolutionary Biology)
Wiberg, R. Axel W. (University of Basel. Department of Environmental Sciences)
Vieira, Jorge (Instituto de Investigação e Inovação em Saúde (Porto, Portugal))
Goubert, Clément (Cornell University. Department of Molecular Biology and Genetics)
Rota-Stabelli, Omar (The European Drosophila Population Genomics Consortium)
Kankare, Maaria (University of Jyväskylä. Department of Biological and Environmental Science)
Bogaerts-Márquez, María (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Haudry, Annabelle (Université Lyon 1. Laboratoire de Biométrie et Biologie Evolutive)
Waidele, Lena (University of Freiburg. Department of Evolutionary Biology and Ecology)
Kozeretska, Iryna (The European Drosophila Population Genomics Consortium)
Pasyukova, Elena G. (The European Drosophila Population Genomics Consortium)
Loeschcke, Volker (Aarhus University. Department of Bioscience-Genetics, Ecology and Evolution)
Pascual, Marta (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Vieira, Cristina P. (The European Drosophila Population Genomics Consortium)
Serga, Svitlana (Taras Shevchenko National University of Kyiv. General and Medical Genetics Department)
Montchamp-Moreau, Catherine (The European Drosophila Population Genomics Consortium)
Abbott, Jessica (Lund University. Department of Biology)
Gibert, Patricia (Université Lyon 1. Laboratoire de Biométrie et Biologie Evolutive)
Porcelli, Damiano (The European Drosophila Population Genomics Consortium)
Posnien, Nico (Universität Göttingen. Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie)
Sánchez-Gracia, Alejandro (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Grath, Sonja (The European Drosophila Population Genomics Consortium)
Sucena, Élio (Universidade de Lisboa. Departamento de Biologia Animal)
Bergland, Alan O. (University of Virginia. Department of Biology)
García Guerreiro, María Pilar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Onder, Banu Sebnem (Hacettepe University. Department of Biology)
Argyridou, Eliza (The European Drosophila Population Genomics Consortium)
Guio, Lain (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Schou, Mads Fristrup (Lund University. Department of Biology)
Deplancke, Bart (The European Drosophila Population Genomics Consortium)
Vieira, Cristina (Université Lyon 1. Laboratoire de Biométrie et Biologie Evolutive)
Ritchie, Michael G. (University of St. Andrews. Centre for Biological Diversity)
Zwaan, Bas J. (Wageningen University. Department of Plant Sciences)
Tauber, Eran (University of Haifa. Department of Evolutionary and Environmental Biology)
Orengo, Dorcas J. (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Puerma, Eva (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Aguadé, Montserrat (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Schmidt, Paul (University of Pennsylvania. Department of Biology)
Parsch, John (Ludwig-Maximilians-Universität München. Division of Evolutionary Biology)
Betancourt, Andrea J. (University of Liverpool. Department of Evolution, Ecology, and Behaviour)
Flatt, Thomas (University of Fribourg. Department of Biology)
González, Josefa (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))

Data:	2020
Resum:	Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatiotemporal patterns of genetic variation in natural populations have been challenging, as comprehensive sampling is logistically difficult, and sequencing of entire populations costly. Here, we address these issues using a collaborative approach, sequencing 48 pooled population samples from 32 locations, and perform the first continent-wide genomic analysis of genetic variation in European Drosophila melanogaster. Our analyses uncover longitudinal population structure, provide evidence for continent-wide selective sweeps, identify candidate genes for local climate adaptation, and document clines in chromosomal inversion and transposable element frequencies. We also characterize variation among populations in the composition of the fly microbiome, and identify five new DNA viruses in our samples.
Ajuts:	European Commission 647900 European Commission 259679 European Commission 036894 Agencia Estatal de Investigación CTM2017-88080 Agencia Estatal de Investigación BFU2017-82937 Ministerio de Economía y Competitividad BFU2014-57779 Ministerio de Economía y Competitividad CGL2013-42432-P Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-880
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Population genomics ; Adaptation, demography ; Selection ; Clines ; SNPs ; Structural variants
Publicat a:	Molecular biology and evolution, Vol. 37, issue 9 (Sep. 2020) , p. 2661-2678, ISSN 1537-1719

DOI: 10.1093/molbev/msaa120
PMID: 32413142

18 p, 5.3 MB

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