ENIGMA MDD : seven years of global neuroimaging studies of major depression through worldwide data sharing
Schmaal, Lianne (The University of Melbourne)
Pozzi, Elena (The University of Melbourne)
C. Ho, Tiffany (University of California)
van Velzen, Laura S. (The University of Melbourne)
Veer, Ilya M. (Humboldt-Universität zu Berlin)
Opel, Nils (University of Münster)
Van Someren, Eus J. W. (Vrije Universiteit Amsterdam)
Han, L.K.M (Vrije Universiteit Amsterdam)
Aftanas, Lybomir (Novosibirsk State University)
Aleman, André (University Medical Center Groningen)
Baune, Bernhard T. (University of Melbourne)
Berger, Klaus (University of Münster)
Blanken, Tessa F. (Vrije Universiteit Amsterdam)
Capitão, Liliana (Oxford Health NHS Foundation Trust)
Couvy-Duchesne, Baptiste (the University of Queensland)
R. Cullen, Kathryn (University of Minnesota)
Dannlowski, Udo (University of Münster)
Davey, Christopher (University of Melbourne)
Erwin-Grabner, Tracy (University Medical Center Göttingen)
Evans, Jennifer (Experimental Therapeutics Branch, NIMH, NIH, Bethesda, MD USA)
Frodl, Thomas (Jena University Hospital (Alemanya))
Fu, Cynthia H. Y. (King's College London)
Godlewska, Beata (Oxford University)
Gotlib, Ian H. (Stanford University)
Goya-Maldonado, Roberto (University Medical Center Göttingen)
Grabe, Hans J. (German Center for Neurodegenerative Diseases)
Groenewold, Nynke A. (University of Cape Town)
Grotegerd, Dominik (University of Münster)
Gruber, Oliver (Heidelberg University Hospital (Alemanya))
Gutman, Boris A. (Illinois Institute of Technology)
Hall, Geoffrey B. (McMaster University (Canadà))
Harrison, Ben J. (The University of Melbourne & Melbourne Health)
Hatton, Sean N. (University of Sydney)
Hermesdorf, Marco (University of Münster)
Hickie, Ian B. (University of Sydney)
Hilland, Eva (University of Oslo.)
Irungu, Benson (The University of Texas)
Jonassen, Rune (Oslo Metropolitan University)
Kelly, Sinead (Harvard Medical School, Boston, MA USA)
Kircher, Tilo (University of Marburg)
Klimes-Dougan, Bonnie (University of Minnesota)
Krug, Axel (University of Marburg)
Landrø, Nils Inge (Diakonhjemmet Hospital)
Lagopoulos, Jim (University of the Sunshine Coast)
Leerssen, Jeanne (Vrije Universiteit Amsterdam)
Li, Meng (Jena University Hospital (Alemanya))
Linden, David E. J. (Cardiff University)
MacMaster, Frank P. (University of Calgary)
McIntosh, Andrew M.. (University of Edinburgh)
Mehler, David M. A. (Cardiff University)
Nenadić, Igor (Marburg University Hospital UKGM, Marburg, Germany)
Penninx, Brenda W. J. H. (Vrije Universiteit Amsterdam)
Portella, Maria J.. (Institut d'Investigació Biomèdica Sant Pau)
Reneman, Liesbeth (location AMC, Amsterdam UMC)
Rentería, Miguel E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Sacchet, Matthew D. (Harvard Medical School)
G. Sämann, Philipp (Max Planck Institute of Psychiatry)
Schrantee, Anouk (location AMC, Amsterdam UMC)
Sim, Kang (National University of Singapore)
Soares, Jair C. (The University of Texas)
Stein, Dan J. (University of Cape Town)
Tozzi, Leonardo (Stanford University)
van Der Wee, Nic J. A. (Leiden University Medical Center)
van Tol, Marie-José (University of Groningen)
Vermeiren, Robert (Leiden University Medical Center)
Vives-Gilabert, Yolanda (Universitat Politècnica de València)
Walter, Henrik (Humboldt-Universität zu Berlin)
Walter, Martin (Leibniz Institute for Neurobiology)
Whalley, Heather (University of Edinburgh)
Wittfeld, Katharina (German Center for Neurodegenerative Diseases)
Whittle, Sarah (The University of Melbourne)
Wright, Margaret J. (The University of Queensland)
Yang, Tony T. (University of California)
Zarate, Carlos (National Institute of Mental Health, Bethesda, MD, USA)
Thomopoulos, Sophia I. (University of Southern California)
Jahanshad, Neda (University of Southern California)
Thompson, Paul M. (University of Southern California)
Veltman, Dick J. (Vrije Universiteit Amsterdam)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research.
Grants:	Instituto de Salud Carlos III CP16-002 European Commission 602450
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Depression ; Neuroscience
Published in:	Translational psychiatry, Vol. 10 (may 2020) , ISSN 2158-3188

DOI: 10.1038/s41398-020-0842-6
PMID: 32472038

19 p, 2.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles