Prescription of Levofloxacin and Moxifloxacin in Select Hospitals in Uganda : A Pilot Study to Assess Guideline Concordance
Nambasa, Victoria (Directorate of Product Safety, Uganda)
Ndagije, Helen B. (Directorate of Product Safety, Uganda)
Serwanga, Allan (Directorate of Product Safety, Uganda)
Manirakiza, Leonard (Directorate of Product Safety, Uganda)
Atuhaire, Joanitah (Directorate of Product Safety, Uganda)
Nakitto, Diana (Directorate of Product Safety, Uganda)
Kiguba, Ronald (Makerere University College of Health Sciences, Uganda)
Figueras, Albert 1961- (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Data:	2020
Resum:	Background : In Uganda, national tuberculosis (TB) treatment guidelines were revised to include the newer generation fluoroquinolones among the second-line treatment options for multidrug-resistant TB. This study was designed to analyze if the prescription of these quinolones is compliant with country recommendations. Methods : This was an observational retrospective study of consumption data for 2017 and 2018 across four selected regional referral hospitals. The sources of consumption data were hospital pharmacy stock cards and the dispensing register. The medical files of patients who had been prescribed fluoroquinolones were also assessed to study compliance with the Uganda Clinical Guidelines and the British National Formulary (BNF). Results : None of the 371 levofloxacin prescriptions analyzed complied with the Uganda Clinical Guidelines, although 250 (67. 3%) were prescribed for indications included in the BNF. According to WHO prescription indicators, only 220 (59. 3%) prescriptions were appropriate. Conclusion : The prescription of levofloxacin and moxifloxacin increased in the hospitals studied, but in a high proportion of cases, they were not compliant with country recommendations. The findings call for the strengthening of national antimicrobial stewardship programs.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Fluoroquinolones ; Multidrug-resistant tuberculosis ; Drug utilization study ; Prescription habits
Publicat a:	Antibiotics, Vol. 9 (july 2020) , ISSN 2079-6382

DOI: 10.3390/antibiotics9080439
PMID: 32717942

10 p, 369.7 KB

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