Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity
Heras-Molina, Ana (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Pesántez-Pacheco, José Luis (University of Cuenca. School of Veterinary Medicine and Zootechnics)
Vázquez-Gómez, Marta (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
García-Contreras, Consolación (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Astiz, Susana (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Isabel, Beatriz (Universidad Complutense de Madrid. Facultad de Veterinaria)
Gonzalez-Bulnes, Antonio (Universidad Complutense de Madrid. Facultad de Veterinaria)

Data:	2020
Resum:	Menopause strongly increases incidence and consequences of obesity and non-communicable diseases in women, with recent research suggesting a very early onset of changes in lipid accumulation, dyslipidemia, and insulin resistance. However, there is a lack of adequate preclinical models for its study. The present trial evaluated the usefulness of an alternative method to surgical ovariectomy, the administration of two doses of a GnRH analogue-protein conjugate (Vacsincel ®), for inducing ovarian inactivity in sows used as preclinical models of obesity and menopause. All the sows treated with the compound developed ovarian stoppage after the second dose and, when exposed to obesogenic diets during the following three months, showed changes in the patterns of fat deposition, in the fatty acids profiles at the different tissues and in the plasma concentrations of fructosamine, urea, β-hydroxibutirate, and haptoglobin when compared to obese fed with the same diet but maintaining ovarian activity. Altogether, these results indicate that menopause early augments the deleterious effects induced by overfeeding and obesity on metabolic traits, paving the way for future research on physiopathology of these conditions and possible therapeutic targets using the swine model.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Models ; Fatty-acids ; Insulin-resistance ; Menopause ; Obesity ; Swine
Publicat a:	Biology, Vol. 9 (september 2020) , ISSN 2079-7737

DOI: 10.3390/biology9090284
PMID: 32932852

16 p, 1.6 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats