Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium : medication matters
Bruin, Willem Benjamin ![Identificador ORCID](/img/uab/orcid.ico)
(University of Amsterdam. Department of Psychiatry)
Taylor, Luke (Anatomy and Genetics. Department of Physiology)
Thomas, Rajat M. (Amsterdam Neuroscience. Amsterdam UMC, University of Amsterdam, Department of Psychiatry)
Shock, Jonathan P. ![Identificador ORCID](/img/uab/orcid.ico)
(University of Cape Town. Department of mathematics and applied mathematics)
Zhutovsky, Paul ![Identificador ORCID](/img/uab/orcid.ico)
(Amsterdam Neuroscience. Amsterdam UMC, University of Amsterdam, Department of Psychiatry)
Abe, Yoshinari ![Identificador ORCID](/img/uab/orcid.ico)
(Kyoto Prefectural University of Medicine. Department of Psychiatry, Graduate School of Medical Science)
Alonso, Pino
(Universitat de Barcelona. Departament de Ciències Clíniques)
Ameis, Stephanie H.
(The Hospital for Sick Children. Centre for Brain and Mental Health)
Anticevic, Alan (Yale University School of Medicine. Department of Psychiatry)
Arnold, Paul D.
(University of Calgary. Department of Psychiatry, Cumming School of Medicine)
Assogna, Francesca (IRCCS Santa Lucia Foundation. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology)
Benedetti, Francesco
(Scientific Institute Ospedale San Raffaele. Psychiatry and Clinical Psychobiology, Division of Neuroscience)
Beucke, Jan C. (Centre for Psychiatric Research and Education, Karolinska Institutet. Department of Clinical Neuroscience)
Boedhoe, Premika (Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience)
Bollettini, Irene
(Scientific Institute Ospedale San Raffaele. Psychiatry and Clinical Psychobiology, Division of Neuroscience)
Bose, Anushree
(Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences)
Brem, Silvia (University of Zurich and ETH Zurich, Neuroscience Center Zurich)
Brennan, Brian P.
(Harvard Medical School)
Buitelaar, Jan
(Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands)
Calvo-Escalona, Rosa
(Centro de Investigación Biomédica en Red de Salud Mental)
Cheng, Yuqi (First Affiliated Hospital of Kunming Medical University. Department of Psychiatry)
Cho, Kang Ik K. (Institute of Human Behavioral Medicine, SNU-MRC)
Dallaspezia, Sara (Scientific Institute Ospedale San Raffaele. Psychiatry and Clinical Psychobiology, Division of Neuroscience)
Denys, Damiaan
(Royal Netherlands Academy of Arts and Sciences. Netherlands Institute for Neuroscience)
Ely, Benjamin A.
(Icahn School of Medicine at Mount Sinai. Department of Psychiatry)
Feusner, Jamie D. (University of California. Department of Psychiatry and Biobehavioral Sciences)
Fitzgerald, Kate D. (University of Michigan. Department of Psychiatry)
Fouche, Jean-Paul
(University of Cape Town. Department of Psychiatry and Mental Health)
Fridgeirsson, Egill A. (Amsterdam Neuroscience. Amsterdam UMC, University of Amsterdam, Department of Psychiatry)
Gruner, Patricia (Yale University School of Medicine. Department of Psychiatry)
Gürsel, Deniz A. (Technische Universität München)
Hauser, Tobias U.
(University College London. Wellcome Centre for Human Neuroimaging)
Hirano, Yoshiyuki
(Chiba University. Research Center for Child Mental Development)
Hoexter, Marcelo Q. (Universidade de Sao Paulo. Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina)
Hu, Hao (Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine)
Huyser, Chaim
(Department of child and adolescent psychiatry Amsterdam UMC, Amsterdam, The Netherlands)
Ivanov, Iliyan (Icahn School of Medicine at Mount Sinai. Division of Child and Adolescent Psychiatry, Department of Psychiatry)
James, Anthony
(Oxford University. Department of Psychiatry)
Jaspers-Fayer, Fern (University of British Columbia)
Kathmann, Norbert
(Humboldt-Universität zu Berlin. Department of Psychology)
Kaufmann, Christian (Humboldt-Universität zu Berlin. Department of Psychology)
Koch, Kathrin (Technische Universität München)
Kuno, Masaru (Chiba University. Research Center for Child Mental Development)
Kvale, Gerd
(University of Bergen. Department of Clinical Psychology)
Kwon, Jun Soo
(Seoul National University College of Natural Sciences. Department of Brain and Cognitive Sciences)
Liu, Yanni (University of Michigan. Department of Psychiatry)
Lochner, Christine
(Stellenbosch University. SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry)
Lázaro, Luisa
(Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Marques, Paulo (Clinical Academic Center-Braga, Braga, Portugal)
Marsh, Rachel
(Columbia University. The Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute)
Martínez-Zalacaín, Ignacio
(Universitat de Barcelona. Departament de Ciències Clíniques)
Mataix-Cols, David
(Karolinska Institutet. Department of Clinical Neuroscience, Centre for Psychiatry Research)
Menchón Magriñá, José Manuel
(Universitat de Barcelona. Departament de Ciències Clíniques)
Minuzzi, Luciano (McMaster University. Department of Psychiatry and Behavioural Neurosciences)
Moreira, Pedro S. (Clinical Academic Center-Braga, Braga, Portugal)
Morer, Astrid (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Morgado, Pedro
(Clinical Academic Center-Braga, Braga, Portugal)
Nakagawa, Akiko (Chiba University. Research Center for Child Mental Development)
Nakamae, Takashi
(Kyoto Prefectural University of Medicine. Department of Psychiatry, Graduate School of Medical Science)
Nakao, Tomohiro (Kyushu University. Department of Neuropsychiatry, Graduate School of Medical Sciences)
Narayanaswamy, Janardhanan C. (Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences)
Nurmi, Erika L.
(University of California. Department of Psychiatry and Biobehavioral Sciences)
O'Neill, Joseph (University of California. Division of Child and Adolescent Psychiatry, Jane and Terry Semel Institute For Neurosciences)
Pariente, Jose C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Perriello, Chris (University of Illinois at Urbana-Champaign)
Piacentini, John
(University of California. Department of Psychiatry and Biobehavioral Sciences)
Piras, Fabrizio
(IRCCS Santa Lucia Foundation. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology)
Piras, Federica
(IRCCS Santa Lucia Foundation. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology)
Reddy, Y. C. Janardhan (Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences)
Rus-Oswald, Oana G.
(University Department of Geriatric Medicine Felix Platter, Basel, Switzerland)
Sakai, Yuki
(ATR Brain Information Communication Research Laboratory Group)
Sato, João R. (Center of Mathematics, Computing and Cognition, Universidade Federal do ABC)
Schmaal, Lianne
(The University of Melbourne. Centre for Youth Mental Health)
Shimizu, Eiji (Graduate School of Medicine, Chiba University. Department of Cognitive Behavioral Physiology)
Simpson, H. Blair (New York State Psychiatric Institute. Center for OCD and Related Disorders)
Soreni, Noam (Offord Child Center, McMaster University)
Soriano-Mas, Carles
(Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Spalletta, Gianfranco
(Baylor College of Medicine. Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences)
Stern, Emily R. (Nathan Kline Institute for Psychiatric Research)
Stevens, Michael C.
(Yale University School of Medicine. Department of Psychiatry)
Stewart, S. Evelyn
(British Columbia Mental Health and Addictions Research Institute)
Szeszko, Philip R. (James J. Peters VA Medical Center, Bronx)
Tolin, David F. (Yale University School of Medicine)
Venkatasubramanian, Ganesan
(Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences)
Wang, Zhen
(Shanghai Key Laboratory of Psychotic Disorders)
Yun, Je-Yeon
(Seoul National University College of Medicine. Yeongeon Student Support Center)
van Rooij, Daan (Radboud University Medical Centre. Department of Cognitive Neuroscience)
Thompson, Paul M. (University of Southern California. Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine)
van den Heuvel, Odile A.
(Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience)
Stein, Dan J.
(University of Cape Town. SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute)
van Wingen, Guido A.
(Amsterdam Neuroscience. Amsterdam UMC, University of Amsterdam, Department of Psychiatry)
Data: |
2020 |
Resum: |
No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair classification performance was achieved when patients were grouped according to their medication status. These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker. |
Ajuts: |
Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1247 Instituto de Salud Carlos III PI040829 Instituto de Salud Carlos III FI17/00294 Instituto de Salud Carlos III CPII16/00048 Instituto de Salud Carlos III PI13/01958 Instituto de Salud Carlos III PI16/00889 Instituto de Salud Carlos III PI14/00419 Fundació la Marató de TV3 01/2010 Fundació la Marató de TV3 091710
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Drets: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by.ico) |
Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
Neuroscience ;
Diagnostic markers |
Publicat a: |
Translational psychiatry, Vol. 10 (october 2020) , ISSN 2158-3188 |
DOI: 10.1038/s41398-020-01013-y
PMID: 33033241
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