Web of Science: 11 cites, Scopus: 12 cites, Google Scholar: cites,
Antimicrobial susceptibility of Neisseria gonorrhoeae in Barcelona during a five-year period, 2013 to 2017
Salmerón, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Viñado, Belén (Hospital Universitari Vall d'Hebron. Institut de Recerca)
El Ouazzani, Rachid (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hernández, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Barberà, Maria Jesús (Universitat de Barcelona)
Alberny, Mireia (Institut Català de la Salut)
Jané i Checa, Mireia (Agència de Salut Pública de Catalunya)
Larrosa, María Nieves (Universitat Autònoma de Barcelona)
Pumarola Suñé, Tomàs (Universitat Autònoma de Barcelona)
Hoyos-Mallecot, Yannick (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Serra-Pladevall, Judit (Universitat Autònoma de Barcelona)

Data: 2020
Resum: Increasing rates of antimicrobial resistance in Neisseria gonorrhoeae cause problems for treating gonorrhoea. This observational study aimed to describe isolates from all patients found infected with N. gonorrhoeae, in Barcelona, Spain, between 2013 and 2017, and with available antimicrobial susceptibility data. Minimum inhibitory concentrations (MICs) of penicillin (PEN), cefixime (CFM), ceftriaxone (CRO), azithromycin (AZM), ciprofloxacin (CIP), spectinomycin (SPT), fosfomycin (FOF) and gentamicin (GEN) were determined by E-test. Susceptibility was assessed using clinical breakpoints from the European Committee on Antimicrobial Susceptibility Testing. Time trends for PEN, CFM, AZM and CIP were investigated using logistic regression. Of 1,979 patients with infection (2,036 isolates), 1,888 (95. 4%) were men. Patient median age was 32 years. The proportions of isolates resistant to extended-spectrum cephalosporins were low, with 0. 3% (5/1,982) resistant to CRO and 4. 9% (98/1,985) to CFM. AZM resistance prevalence was 2. 7% (52/1,981), including 16 isolates detected in 2016 and 2017, with high-level resistance. For CIP, 51. 3% (1,018/1,986) of isolates were resistant, and for PEN, 20. 1% (399/1,985). All isolates were susceptible to SPT. MIC and MIC values of GEN were 4 and 6 mg/L and of FOF 12 and 24 mg/L, respectively. Between 2013 and 2017, PEN and CFM resistance rates each decreased from 28. 1% (92/327) to 12. 2% (70/572) and from 8. 3% (27/327) to 4. 4% (25/572) (p ≤ 0. 0073). In contrast, AZM resistance prevalence appeared to increase from 1. 5% in 2014 (5/340) to 3. 0% (17/572) in 2017. No trend was identified for CIP. Antimicrobial susceptibility surveillance is important to timely detect new phenotypes and trends.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Neisseria gonorrhoeae ; Antimicrobial resistance ; Extended-spectrum cephalosporins ; Azithromycin
Publicat a: Eurosurveillance, Vol. 25 (october 2020) , ISSN 1560-7917

DOI: 10.2807/1560-7917.ES.2020.25.42.1900576
PMID: 33094716


9 p, 215.5 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2022-02-07, darrera modificació el 2023-10-18



   Favorit i Compartir