Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study
de Havenon, Adam (University of Utah)
Narata, Ana Paula (University Hospital of Tours)
Amelot, Aymeric (Hopital Universitaire Pitie Salpetriere)
Saver, Jeffrey L.. (UCLA)
Bozorgchami, Hormozd (Oregon Health and Science University)
Mattle, Heinrich Paul (University of Bern)
Ribo, Marc (Universitat Autònoma de Barcelona)
Andersson, Tommy (Karolinska University Hospital and Karolinska Institutet (Suècia))
Zaidat, Osama (Mercy Health St Vincent Medical Center)

Date:	2020
Abstract:	The benefit of endovascular thrombectomy for acute ischemic stroke with M2 segment middle cerebral artery occlusion remains controversial, with uncertainty and paucity of data specific to this population. To compare outcomes between M1 and M2 occlusions in the Analysis of Revascularization in Ischemic Stroke with EmboTrap (ARISE II) trial. We performed a prespecified analysis of the ARISE II trial with the primary outcome of 90-day modified Rankin Scale score of 0-2, which we termed good outcome. Secondary outcomes included reperfusion rates and major adverse events. The primary predictor was M2 occlusion, which we compared with M1 occlusion. We included 183 patients, of whom 126 (69%) had M1 occlusion and 57 (31%) had M2 occlusion. There was no difference in the reperfusion rates or adverse events between M2 and M1 occlusions. The rate of good outcome was not different in M2 versus M1 occlusions (70. 2% vs 69. 7%, p=0. 946). In a logistic regression model adjusted for age, sex, and baseline National Institutes of Health Stroke Scale score, M2 occlusions did not have a significantly different odds of good outcome compared with M1 occlusions (OR 0. 94, 95% CI 0. 47 to 1. 88, p=0. 87). In ARISE II, M2 occlusions achieved a 70. 2% rate of good outcome at 90 days, which is above published rates for untreated M2 occlusions and superior to prior reports of M2 occlusions treated with endovascular thrombectomy. We also report similar rates of good outcome, successful reperfusion, death, and other adverse events when comparing the M1 and M2 occlusions.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Stroke ; Angiography ; Brain ; Thrombectomy
Published in:	Journal of Neurointerventional Surgery, Vol. 13 (november 2020) , p. 779-783, ISSN 1759-8486

DOI: 10.1136/neurintsurg-2020-016427
PMID: 33219148

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