Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression
Jolly, Mohit Kumar (Indian Institute of Science)
Celià-Terrassa, Toni (Institut Hospital del Mar d'Investigacions Mèdiques)

Data:	2019
Resum:	Genetic and phenotypic heterogeneity contribute to the generation of diverse tumor cell populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to genetic heterogeneity, a consequence of mutational events, phenotypic heterogeneity arises from dynamic, reversible cell state transitions in response to varying intracellular/extracellular signals. Such phenotypic plasticity enables rapid adaptive responses to various stressful conditions and can have a strong impact on cancer progression. Herein, we have reviewed relevant literature on mechanisms associated with dynamic phenotypic changes and cellular plasticity, such as epithelial-mesenchymal transition (EMT) and cancer stemness, which have been reported to facilitate cancer metastasis. We also discuss how non-cell-autonomous mechanisms such as cell-cell communication can lead to an emergent population-level response in tumors. The molecular mechanisms underlying the complexity of tumor systems are crucial for comprehending cancer progression, and may provide new avenues for designing therapeutic strategies.
Ajuts:	Instituto de Salud Carlos III MS17/00037 Instituto de Salud Carlos III PI18/00014
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cellular dynamics ; Epithelial-to-mesenchymal transition ; Cell plasticity ; Cancer stem cells ; Mathematical modeling ; Population homeostasis
Publicat a:	Journal of clinical medicine, Vol. 8 (september 2019) , ISSN 2077-0383

DOI: 10.3390/jcm8101542
PMID: 31557977

19 p, 995.7 KB

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