The molecular genealogy of sequential overlapping inversions implies both homologous chromosomes of a heterokaryotype in an inversion origin
Orengo, Dorcas J. (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Puerma, Eva (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Cereijo, Unai (Centre de Recerca en Agrigenòmica)
Aguadé, Montserrat (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)

Date:	2019
Abstract:	Cytological and molecular studies have revealed that inversion chromosomal polymorphism is widespread across taxa and that inversions are among the most common structural changes fixed between species. Two major mechanisms have been proposed for the origin of inversions considering that breaks occur at either repetitive or non-homologous sequences. While inversions originating through the first mechanism might have a multiple origin, those originating through the latter mechanism would have a unique origin. Variation at regions flanking inversion breakpoints can be informative on the origin and history of inversions given the reduced recombination in heterokaryotypes. Here, we have analyzed nucleotide variation at a fragment flanking the most centromere-proximal shared breakpoint of several sequential overlapping inversions of the E chromosome of Drosophila subobscura -inversions E, E, E and E. The molecular genealogy inferred from variation at this shared fragment does not exhibit the branching pattern expected according to the sequential origin of inversions. The detected discordance between the molecular and cytological genealogies has led us to consider a novel possibility for the origin of an inversion, and more specifically that one of these inversions originated on a heterokaryotype for chromosomal arrangements. Based on this premise, we propose three new models for inversions origin.
Grants:	Ministerio de Economía y Competitividad BFU2012-35168 Ministerio de Economía y Competitividad BFU2015-63732 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1055 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1287
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Evolution ; Genetics
Published in:	Scientific reports, Vol. 9 (November 2019) , art. 17009, ISSN 2045-2322

DOI: 10.1038/s41598-019-53582-8
PMID: 31740730

11 p, 2.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > CRAG (Centre for Research in Agricultural Genomics)
Articles > Research articles
Articles > Published articles