Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
Klein, Alison P. (Johns Hopkins School of Medicine, Baltimore, USA)
Wolpin, Brian M. (Dana-Farber Cancer Institute, Boston, USA)
Risch, Harvey A. (Yale School of Public Health, New Haven, USA)
Stolzenberg-Solomon, Rachael Z. (National Institutes of Health, Bethesda, USA)
Mocci, Evelina (Johns Hopkins School of Medicine, Baltimore, USA)
Zhang, Mingfeng (National Cancer Institute, National Institutes of Health, Bethesda, USA)
Canzian, Federico (Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany)
Childs, Erica J. (Johns Hopkins School of Medicine, Baltimore, USA)
Hoskins, Jason W. (National Cancer Institute, National Institutes of Health, Bethesda, USA)
Jermusyk, Ashley (National Cancer Institute, National Institutes of Health, Bethesda, USA)
Zhong, Jun (National Cancer Institute, National Institutes of Health, Bethesda, USA)
Chen, Fei (Johns Hopkins School of Medicine, Baltimore, USA)
Albanes, Demetrius (National Cancer Institute, National Institutes of Health, Bethesda, USA)
Andreotti, Gabriella (National Institutes of Health, Bethesda, USA)
Arslan, Alan A. (New York University School of Medicine, New York, USA)
Babic, Ana (Dana-Farber Cancer Institute, Boston, USA)
Bamlet, William R. (Mayo Clinic College of Medicine, Rochester, USA)
Beane-Freeman, Laura (National Cancer Institute, National Institutes of Health, Bethesda, USA)
Berndt, Sonja (National Institutes of Health, Bethesda, USA)
Blackford, Amanda (Johns Hopkins School of Medicine, Baltimore, USA)
Borges, Michael (Johns Hopkins School of Medicine, Baltimore, USA)
Borgida, Ayelet (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, M5G 1×5, Canada.)
Bracci, Paige M. (University of California, San Francisco, USA)
Brais, Lauren (Dana-Farber Cancer Institute, Boston, USA)
Brennan, Paul (International Agency for Research on Cancer (IARC), Lyon, France)
Brenner, Hermann (Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany)
Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands)
Buring, Julie (Division of Preventive Medicine, Brigham and Women's Hospital, Boston)
Campa, Daniele (University of Pisa)
Capurso, Gabriele (University of Rome)
Cavestro, Giulia Martina (Vita-Salute San Raffaele University, Milan)
Chaffee, Kari G (Mayo Clinic College of Medicine, Rochester, USA)
Chung, Charles C. (National Institutes of Health, Bethesda, USA)
Cleary, Sean (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada)
Cotterchio, Michelle (University of Toronto.)
Dijk, Frederike (University of Amsterdam. Department of Pathology, Academic Medical Center)
Duell, Eric J. (Institut d'Investigació Biomèdica de Bellvitge)
Foretova, Lenka (Masaryk Memorial Cancer Institute. Department of Cancer Epidemiology and Genetics, Brno, Czech Republic.)
Fuchs, Charles (Yale Cancer Center, New Haven, USA)
Funel, Niccola (University of Pisa.)
Gallinger, Steven (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada)
M. Gaziano, J. Michael (Boston VA Healthcare System)
Gazouli, Maria (National and Kapodistrian University of Athens)
Giles, Graham G. (Monash University. Department of Epidemiology and Preventive Medicine, Melbourne, Australia)
Giovannucci, Edward (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica))
Goggins, Michael (Johns Hopkins School of Medicine. Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Baltimore)
Goodman, Gary E. (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences, Seattle, USA)
Goodman, Phyllis J. (Fred Hutchinson Cancer Research Center. SWOG Statistical Center, Seattle, USA)
Hackert, Thilo (University Hospital Heidelberg, Germany)
Haiman, Christopher A (University of Southern California, USA)
Hartge, Patricia (National Institutes of Health, Bethesda, USA)
Hasan, Manal (University of Texas MD Anderson Cancer Center, USA)
Hegyi, Peter (University of Szeged, Szeged, Hungary)
Helzlsouer, Kathy J. (National Institutes of Health, Bethesda, USA)
Herman, Joseph (Johns Hopkins School of Medicine. Baltimore, USA)
Holcatova, Ivana (Charles University, Prague, Czech Republic)
Holly, Elizabeth A. (University of California, San Francisco)
Hoover, Robert (National Institutes of Health, Bethesda, USA)
Hung, Rayjean J. (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada)
Jacobs, Eric J. (American Cancer Society. Epidemiology Research Program, Atlanta)
Jamroziak, Krzysztof (Institute of Hematology and Transfusion Medicine, Warsaw, Poland)
Janout, Vladimir (Faculty of Medicine, University of Olomouc, Czech Republic)
Kaaks, Rudolf (German Cancer Research Center (DKFZ), Heidelberg, Germany)
Khaw, Kay-Tee (University of Cambridge)
Klein, Eric A. (Cleveland Clinic)
Kogevinas, M (Hospital del Mar (Barcelona, Catalunya))
Kooperberg, Charles (Fred Hutchinson Cancer Research Center, Seattle)
Kulke, Matthew H. (Dana-Farber Cancer Institute, Boston)
Kupcinskas, Juozas (Lithuanian University of Health Sciences, Kaunas, Lithuania)
Kurtz, Robert J. (Memorial Sloan Kettering Cancer Center, New York, USA)
Laheru, Daniel (Johns Hopkins School of Medicine, Baltimore, USA)
Landi, Stefano (University of Pisa)
Lawlor, Rita T. (University and Hospital Trust of Verona)
Lee, I.-Min (Harvard School of Public Health, Boston)
LeMarchand, Loic (University of Hawaii Cancer Center, Honolulu, USA)
Lu, Lingeng (Yale School of Public Health, New Haven, USA)
Malats, Núria (Centro de Investigación Biomédica en Red de Cáncer, Madrid)
Mambrini, Andrea (Oncology Department, ASL1 Massa Carrara, Italy)
Mannisto, Satu (National Institute for Health and Welfare, Helsinki, Finland)
Milne, Roger L. (The University of Melbourne, Australia)
Mohelníková-Duchoňová, Beatrice (Palacky University Olomouc and University Hospital, Czech Republic)
Neale, Rachel E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Neoptolemos, John P. (University of Heidelburg, Heidelberg, Germany)
Oberg, Ann L. (Mayo Clinic College of Medicine, Rochester, USA)
Olson, Sara H. (Memorial Sloan Kettering Cancer Center, New York, USA)
Orlow, Irene (Memorial Sloan Kettering Cancer Center, New York, USA)
Pasquali, Claudio (University of Padua, Italy)
Patel, Alpa V. (American Cancer Society, Atlanta)
Peters, Ulrike (Fred Hutchinson Cancer Research Center, Seattle)
Pezzilli, Raffaele (Sant'Orsola-Malpighi Hospital, Bologna, Italy)
Porta, Miquel 1957- (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Real, Francisco X. (Universitat Pompeu Fabra)
Rothman, Nathaniel (National Institutes of Health, Bethesda, USA)
Scelo, Ghislaine (International Agency for Research on Cancer (IARC), Lyon, France)
Sesso, Howard D. (Harvard T.H. Chan School of Public Health. Department of Epidemiology)
Severi, Gianluca (Université Paris-Saclay, France)
Shu, Xiao-Ou (Vanderbilt University School of Medicine, Nashville, USA)
Silverman, Debra (National Institutes of Health, Bethesda, USA)
Smith, Jill P. (Georgetown University, Washington, USA)
Soucek, Pavel (Charles University, Pilsen, Czech Republic.)
Sund, Malin (Umeå University, Sweden)
Talar-Wojnarowska, Renata (Medical University of Łodz, Poland)
Tavano, Francesca (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS), Italy)
Thornquist, Mark D. (Fred Hutchinson Cancer Research Center, Seattle)
Tobias, Geoffrey S. (National Institutes of Health, Bethesda, USA)
Van Den Eeden, Stephen K. (Kaiser Permanente Northern California, USA)
Vashist, Yogesh (University Hamburg-Eppendorf, Germany)
Visvanathan, Kala (Johns Hopkins Bloomberg School of Public Health, Baltimore, USA)
Vodicka, Pavel (Academy of Sciences of the Czech Republic, Prague, Czech Republic)
Wactawski-Wende, Jean (University at Buffalo, USA)
Wang, Zhaoming (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica))
Wentzensen, Nicolas (National Cancer Institute, National Institutes of Health, Bethesda, USA)
White, Emily (University of Washington, USA)
Yu, Herbert (University of Hawaii Cancer Center, USA)
Yu, Kai (National Institutes of Health, Bethesda, USA)
Zeleniuch-Jacquotte, Anne (New York University School of Medicine, USA)
Zheng, Wei (Vanderbilt University School of Medicine, Nashville, USA)
Kraft, Peter (Harvard School of Public Health, USA)
Li, Donghui (University of Texas MD Anderson Cancer Center, USA)
Chanock, Stephen (National Institutes of Health, Bethesda, USA)
Obazee, Ofure (German Cancer Research Center (DKFZ), Heidelberg, Germany)
Petersen, Gloria M. (Mayo Clinic College of Medicine, Rochester, USA)
Amundadottir, Laufey T. (National Cancer Institute (Bethesda, Estats Units d'Amèrica))

Data:	2018
Resum:	In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/ TNS3, P = 4. 35 × 10 −8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36. 33 (NOC2L, P = 8. 36 × 10 −14), rs2941471 at 8q21. 11 (HNF4G, P = 6. 60 × 10 −10), rs4795218 at 17q12 (HNF1B, P = 1. 32 × 10 −8), and rs1517037 at 18q21. 32 (GRP, P = 3. 28 × 10 −8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Ajuts:	Ministerio de Economía y Competitividad PI13/00082 Ministerio de Economía y Competitividad PI15/01573
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Nature communications, Vol. 9 (february 2018) , ISSN 2041-1723

DOI: 10.1038/s41467-018-02942-5
PMID: 29422604

11 p, 1.8 MB

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