Abnormalities in gray matter volume in patients with borderline personality disorder and their relation to lifetime depression : A VBM study
Aguilar-Ortiz, Salvatore (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Salgado-Pineda, Pilar (Centro de Investigación Biomédica en Red de Salud Mental)
Marco-Pallarés, Josep (Institut d'Investigació Biomèdica de Bellvitge)
Pascual Mateos, Juan Carlos (Institut d'Investigació Biomèdica Sant Pau)
Vega, Daniel (Consorci Sanitari de l'Anoia, Igualada)
Soler, Joaquim (Institut d'Investigació Biomèdica Sant Pau)
Brunel, Cristina (Benito Menni Centre Assistencial en Salut Mental (Sant Boi de Llobregat))
Martin Blanco, Ana (Institut d'Investigació Biomèdica Sant Pau)
Soto, Angel (Consorci Sanitari de l'Anoia, Igualada)
Ribas, Joan (Consorci Sanitari de l'Anoia, Igualada)
Maristany, Teresa (Hospital Sant Joan de Déu (Manresa))
Sarró, Salvador (Centro de Investigación Biomédica en Red de Salud Mental)
Salvador, Raymond (Centro de Investigación Biomédica en Red de Salud Mental)
Rodríguez-Fornells, Antoni (Institut d'Investigació Biomèdica de Bellvitge)
Pomarol-Clotet, Edith (Centro de Investigación Biomédica en Red de Salud Mental)
McKenna, Peter J. (Centro de Investigación Biomédica en Red de Salud Mental)

Date:	2018
Abstract:	Structural imaging studies of borderline personality disorder (BPD) have found regions of reduced cortical volume, but these have varied considerably across studies. Reduced hippocampus and amygdala volume have also been a regular finding in studies using conventional volumetric measurement. How far comorbid major depression, which is common in BPD and can also affect in brain structure, influences the findings is not clear. Seventy-six women with BPD and 76 matched controls were examined using whole-brain voxel-based morphometry (VBM). The hippocampus and amygdala were also measured, using both conventional volume measurement and VBM within a mask restricted to these two subcortical structures. Lifetime history of major depression was assessed using structured psychiatric interview. At a threshold of p = 0. 05 corrected, the BPD patients showed clusters of volume reduction in the dorsolateral prefrontal cortex bilaterally and in the pregenual/subgenual medial frontal cortex. There was no evidence of volume reductions in the hippocampus or amygdala, either on conventional volumetry or using VBM masked to these regions. Instead there was evidence of right-sided enlargement of these structures. No significant structural differences were found between patients with and without lifetime major depression. According to this study, BPD is characterized by a restricted pattern of cortical volume reduction involving the dorsolateral frontal cortex and the medial frontal cortex, both areas of potential relevance for the clinical features of the disorder. Previous findings concerning reduced hippocampus and amygdala volume in the disorder are not supported. Brain structural findings in BPD do not appear to be explainable on the basis of history of associated lifetime major depression.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1573 Instituto de Salud Carlos III CP10/00596 Instituto de Salud Carlos III CP13/00018
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 13 (february 2018) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0191946
PMID: 29466364

14 p, 2.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles