guest ::
| Home > Articles > Published articles > Circulating monocyte subsets and heart failure prognosis |
| Home > Articles > Published articles > Circulating monocyte subsets and heart failure prognosis |
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol) (Universitat Autònoma de Barcelona. Departament de Medicina) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Universitat Autònoma de Barcelona. Departament de Medicina) (Hospital Clínic Universitari (València)) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
| Date: | 2018 |
| Abstract: | Monocytes are a heterogeneous population of effector cells with key roles in tissue integrity restoration and maintenance. Here, we explore the association of monocyte subsets and prognosis in patients with ambulatory heart failure (HF). Monocyte subsets were classified as classical (CD14 ++ /CD16 -), intermediate (CD14 ++ /CD16 +), or non-classical (CD14 + /CD16 ++). Percentage distribution and absolute cell count were assessed in each subset, and multivariable Cox regression analyses were performed with all-cause death, HF-related hospitalization, and the composite end-point of both as dependent variables. 400 patients were consecutively included (72. 8% male, age 69. 4±12. 2 years, 45. 5% from ischemic aetiology, left ventricle ejection fraction (LVEF) 41. 6% ±14. 5, New York Heart Association (NYHA) class II 62. 8% and III 30. 8%). During a mean follow-up of 2. 6±0. 9 years, 107 patients died, 99 had a HF-related hospitalization and 160 suffered the composite end-point of all-cause death or HF-related hospitalization. Monocyte subsets assessed in percentages were not independently associated to any of the end-points. When considering number of cells/μL, intermediate subset was independently associated with an increase of all-cause death (HR 1. 25 [95% CI 1,02-1. 52], p = 0. 03), and the composite end-point HR 1. 20 [95% CI 1,03-1. 40], p = 0. 02). The presented findings show that absolute cell count of monocyte subsets was preferred over monocyte percentage for prognosis stratification for outpatients with HF. The intermediate monocyte subset provides information on increased risk of all-cause death and the composite end-point. |
| Grants: | Agencia Estatal de Investigación SAF2017-84324-C2-1-R Ministerio de Economía y Competitividad CB16/11/00403 Ministerio de Economía y Competitividad RD16/0011/0006 Instituto de Salud Carlos III FISPI17/01487 |
| Note: | Altres ajuts: Fundacio' La MARATO' de TV3 (201502 to ABG, 201516), AdvanceCat with the support of ACCIÓ [Catalonia Trade & Investment, Generalitat de Catalunya], Fundació Bancària La Caixa. |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Published in: | PloS one, Vol. 13 Núm. 9 (september 2018) , ISSN 1932-6203 |
