Characterization and implications of the dynamics of eosinophils in blood and in the infarcted myocardium after coronary reperfusion
Rios-Navarro, Cesar (Hospital Clínic Universitari (València))
Gavara Doñate, Jose (Hospital Clínic Universitari (València))
Vidal, Veronica (Universitat de València)
Bonanad, Clara (Hospital Clínic Universitari (València))
Racugno, Paolo (Hospital Clínic Universitari (València))
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Miñana, Gema (Hospital Clínic Universitari (València))
Husser, Oliver (St. Johannes Hospital(Alemania))
Oltra, Ricardo (Hospital Clínic Universitari (València))
Núñez, Julio (Hospital Clínic Universitari (València))
Chorro, Francisco J. (Hospital Clínic Universitari (València))
Bodi, Vicente (Hospital Clínic Universitari (València))
Ruiz-Sauri, Amparo (Universitat de València)

Data:	2018
Resum:	We characterized the dynamics of eosinophils in blood and in the infarcted myocardium in patients and in a swine model of reperfused myocardial infarction (MI). The association of eosinophil dynamics with various outcomes was assessed. Serial eosinophil count and pre-discharge cardiac magnetic resonance were carried out in a prospective series of 620 patients with a first ST-elevation MI. In a swine model of reperfused MI, the dynamics of circulating eosinophils and their presence in the infarcted myocardium were determined. In autopsies from chronic MI patients, eosinophils were quantified. Patient eosinophil count sharply decreased 12h post-reperfusion compared to arrival. A lower minimum eosinophil count was associated with more extensive edema, microvascular obstruction, and infarct size as measured by cardiac magnetic resonance, and also with a higher rate of cardiac events (death, re-infarction, or heart failure) during follow-up. In the experimental model, eosinophil count boosted during ischemia and dropped back immediately post-reperfusion. Myocardial samples revealed progressive eosinophil migration into the infarcted myocardium, especially areas with microvascular obstruction. Markers of eosinophil maturation and survival (interleukin-5), degranulation (eosinophil cationic protein) and migration (eotoxin-1) were detected in the blood of patients, and in porcine myocardium. Eosinophil infiltration was detected in autopsies from chronic MI patients. Eosinopenia post-MI was associated with an impaired cardiac structure and adverse events. The decay in circulating eosinophils soon after reperfusion mirrors their migration into the infarcted myocardium, as reflected by their presence in heart samples from swine and patients. Further studies are needed to understanding this unexplored pathway and its therapeutic implications.
Ajuts:	Instituto de Salud Carlos III PI17/01836 Ministerio de Economía y Competitividad PIE15/00013 Ministerio de Economía y Competitividad CB16/11/00486
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 13 (october 2018) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0206344
PMID: 30365558

20 p, 2.6 MB

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