Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells
Gener, Petra (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Callejo, Patricia González (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Andrade, Fernanda (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Martínez, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Montero, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Sayós, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC phenotypes and vice versa, to ensure the necessary balance within the tumor. Likewise, cancer cells can switch between epithelial and mesenchymal phenotypes via well-described transition (EMT/MET) that is thought to be crucial for tumor propagation. In this review, we discuss whether, and to which extend, the CSCs and mesenchymal cancer cells are overlapping phenomena in terms of mechanisms, origin, and implication for cancer treatment. As well, we describe the dynamism of both phenotypes and involvement of the tumor microenvironment in CSC reversion and in EMT.
Grants:	Instituto de Salud Carlos III PI17/02242 Ministerio de Economía, Industria y Competitividad PI14/02079
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Stem Cells International, Vol. 2018 (october 2018) , ISSN 1687-9678

DOI: 10.1155/2018/4516454
PMID: 30405720

12 p, 2.8 MB

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